M4255
3-Methoxy-L-tyrosine monohydrate
≥98% (HPLC)
Synonym(s):
4-Hydroxy-3-methoxy-L-phenylalanine, L-3-O-Methyl-DOPA
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About This Item
Empirical Formula (Hill Notation):
C10H13NO4 H2O
CAS Number:
Molecular Weight:
229.23
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
MDL number:
Product Name
3-Methoxy-L-tyrosine monohydrate, powder
SMILES string
COc1cc(C[C@H](N)C(O)=O)ccc1O
InChI
1S/C10H13NO4/c1-15-9-5-6(2-3-8(9)12)4-7(11)10(13)14/h2-3,5,7,12H,4,11H2,1H3,(H,13,14)/t7-/m0/s1
InChI key
PFDUUKDQEHURQC-ZETCQYMHSA-N
assay
≥98% (HPLC)
form
powder
application(s)
detection
storage temp.
2-8°C
Quality Level
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Biochem/physiol Actions
The major metabolite of L-DOPA via catechol O-methyltransferase (COMT). 3-methoxy-L-tyrosine is neither a substrate for nor an inhibitor of L-amino acid decarboxylase activity. Inhibition of COMT enhances the anti-Parkinson activity of L-DOPA.
3-Methoxy-L-tyrosine is a metabolite of L-Dopa.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Chiara Muzzi et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 62(4), 253-258 (2007-12-26)
Levodopa is the medication of choice for Parkinson's disease. The biological complexity of levodopa and of its main derivatives makes their determination important in the clinical field. The aim of this study was to develop an HPLC method for the
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