M4414
Myristoyl coenzyme A lithium salt
≥80.0% (HPLC), powder, protein myristoylation substrate
Synonym(s):
n-Tetradecanoyl Coenzyme A lithium salt
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About This Item
Empirical Formula (Hill Notation):
C35H62N7O17P3S · xLi+
CAS Number:
Molecular Weight:
977.89 (free acid basis)
UNSPSC Code:
12352202
NACRES:
NA.77
Assay:
≥80.0%
Quality level:
General description
Long chain fatty acid (C14) covalently linked to Coenzyme A. Substrate for de novo fatty acid synthesis. Fatty acylation has been shown to block G protein-associated calcium release by a direct allosteric modification of a component of the GTP-activated process.
Biochem/physiol Actions
Myristoyl coenzyme A is a combination of coenzyme A and myristate. It serves as a substrate in protein myristoylation, catalyzed by the enzyme N-myristoyl transferase. Myristyolation involves the transfer of the myristoyl group to the glycine residue at the amino-terminal of the protein.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Articles
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Signal Transduction - Single Cell Techniques, 327-327 (2008)
K E Rys-Sikora et al.
The Journal of biological chemistry, 269(50), 31607-31613 (1994-12-16)
A sensitive and specific GTP-activated Ca2+ translocation process induces rapid Ca2+ movements within cells and appears to reflect G protein-induced membrane fusion or junctional communication between discrete subpopulations of Ca(2+)-pumping organelles (Ghosh, T. K., Mullaney, J. M., Tarazi, F. I.
Functional significance of myristoyl moiety in N-myristoyl proteins.
L J Knoll et al.
Methods in enzymology, 250, 405-435 (1995-01-01)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M4414-5MG | 04061834058946 |