M5199
Meldonium dihydrate
≥98% (HPLC), BBOX inhibitor, powder
Synonym(s):
MET 88, Quaterin
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About This Item
Empirical Formula (Hill Notation):
C6H14N2O2 · 2H2O
CAS Number:
Molecular Weight:
182.22
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Meldonium dihydrate, ≥98% (HPLC), powder
SMILES string
C[N+](C)(C)NCCC([O-])=O
InChI key
PVBQYTCFVWZSJK-UHFFFAOYSA-N
InChI
1S/C6H14N2O2/c1-8(2,3)7-5-4-6(9)10/h7H,4-5H2,1-3H3
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to off-white
solubility
H2O: >40 mg/mL
storage temp.
2-8°C
Quality Level
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Application
Meldonium dihydrate has been used as an anti-ischemic agent to evaluate its protective effects on Ischemia-reperfusion (I/R) in chick embryos.
Biochem/physiol Actions
Meldonium exhibits anti-ischemic activity and shows therapeutic effects against cerebral and cardiac ischemic disorders.
Meldonium is an Inhibitor of γ-butyrobetaine hydroxylase (BBOX) a key enzyme in the synthesis of carnitine.
Meldonium is an inhibitor of γ-butyrobetaine hydroxylase (BBOX).
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
监管及禁止进口产品
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Meldonium: Pharmacological, toxicological, and analytical aspects
Berlato D G and Bairros A
Toxicological Research, 4 (2020)
Eram Fauzia et al.
Frontiers in pharmacology, 9, 1034-1034 (2018-10-10)
Ischemia-reperfusion (I/R)-related disorders, such as stroke, myocardial infarction, and peripheral vascular disease, are among the most frequent causes of disease and death. Tissue injury or death may result from the initial ischemic insult, primarily determined by the magnitude and duration
Sylwia Magiera et al.
Journal of AOAC International, 97(6), 1526-1537 (2015-01-30)
A rapid and sensitive ultra-HPLC/MSIMS (UHPLC/MSIMS) assay method for the simultaneous determination in human urine of 22 drugs belonging to different pharmaceutical groups was developed. The drugs were extracted from urine samples and then separated on a Zorbax Rapid Resolution
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