M5324
PX 12
≥98% (HPLC), powder
Synonym(s):
2-[(1-methylpropyl)dithio]-1H-imidazole
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About This Item
Empirical Formula (Hill Notation):
C7H12N2S2
CAS Number:
Molecular Weight:
188.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Product Name
PX 12, ≥98% (HPLC), powder
InChI key
BPBPYQWMFCTCNG-UHFFFAOYSA-N
SMILES string
CCC(C)SSc1ncc[nH]1
InChI
1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)
assay
≥98% (HPLC)
form
powder
color
off-white to tan
solubility
DMSO: >25 mg/mL
storage temp.
2-8°C
Quality Level
Related Categories
Application
PX 12 has been used as a thioredoxin 1 inhibitor prostate cancer cell lines to analyse its effect on cell viability. It has also been used as a hypoxia-inducible factor (HIF)-1α inhibitor to treat H2228 cells.
Biochem/physiol Actions
PX 12 is a thioredoxin inhibitor.
PX-12 inhibits the thioredoxin redox system and HIF-1a activity. PX 12 inhibits hypoxia-induced HIF-1a transcriptional activity (IC50 11 nM) and proliferation of HT29 and MCF-7 tumor cells (IC50 1.9 and 0.9 uM, respectively).
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Huiwen Ren et al.
Plastic and reconstructive surgery, 142(1), 23e-33e (2018-04-13)
Thioredoxin-1 plays an important role in protecting the skin flap from ischemia-reperfusion injury. Ganoderma lucidum polysaccharide peptide is the major component of G. lucidum, which possesses potent antioxidant and antiapoptotic activity. This study aims to determine whether G. lucidum polysaccharide
Narin Changklungmoa et al.
Parasitology research, 113(6), 2335-2343 (2014-04-11)
In the present study, a cDNA encoding Trx from F. gigantica (FgTrx) was cloned by polymerase chain reaction (PCR). The sequence of FgTrx, analyzed by BLAST, SignalP, and ClustralW programs, showed 315 bp of an open reading frame (ORF), 12 bp 5'UTR
EML4-ALK enhances programmed cell death-ligand 1 expression in pulmonary adenocarcinoma via hypoxia-inducible factor (HIF)-1alpha and STAT3
Koh J, et al.
Oncoimmunology, 5(3), e1108514-e1108514 (2016)
Marissa Opelt et al.
Molecular pharmacology, 93(4), 335-343 (2018-01-24)
According to current views, oxidation of aldehyde dehydrogenase-2 (ALDH2) during glyceryltrinitrate (GTN) biotransformation is essentially involved in vascular nitrate tolerance and explains the dependence of this reaction on added thiols. Using a novel fluorescent intracellular nitric oxide (NO) probe expressed
Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer
Samaranayake GJ, et al.
Nature Communications, 8(1), 1204-1204 (2017)
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