主要文件

查看所有文档

M5324

PX 12

Name: PX 12
Brand: SIGMA

≥98% (HPLC), powder

别名:

2-[(1-methylpropyl)dithio]-1H-imidazole

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₇H₁₂N₂S₂

化学文摘社编号:

141400-58-0

分子量:

188.31

NACRES:

NA.77

PubChem Substance ID:

329818011

UNSPSC Code:

12352200

MDL number:

MFCD18086851

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

off-white to tan

solubility

DMSO: >25 mg/mL

storage temp.

2-8°C

SMILES string

CCC(C)SSc1ncc[nH]1

InChI

1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)

InChI key

BPBPYQWMFCTCNG-UHFFFAOYSA-N

说明

Application

PX 12 已被用作硫氧还蛋白 1 抑制剂前列腺癌细胞系，以分析其对细胞活力的影响。也曾作为缺氧诱导因子 (HIF)-1α抑制剂处理 H2228 细胞。

Biochem/physiol Actions

PX 12 是硫氧还蛋白抑制剂。

PX-12 抑制硫氧还蛋白氧化还原系统和 HIF-1a 活性。PX 12 抑制缺氧诱导的 HIF-1a 转录活性（IC50 11 nM）和 HT29 和 MCF-7 肿瘤细胞的增殖（IC50 分别为 1.9 和 0.9 μM）。

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000540590

0000150531

0000102828

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Sustained Formation of Nitroglycerin-Derived Nitric Oxide by Aldehyde Dehydrogenase-2 in Vascular Smooth Muscle without Added Reductants: Implications for the Development of Nitrate Tolerance.

Marissa Opelt et al.

Molecular pharmacology, 93(4), 335-343 (2018-01-24)

According to current views, oxidation of aldehyde dehydrogenase-2 (ALDH2) during glyceryltrinitrate (GTN) biotransformation is essentially involved in vascular nitrate tolerance and explains the dependence of this reaction on added thiols. Using a novel fluorescent intracellular nitric oxide (NO) probe expressed

Identification and expression of Fasciola gigantica thioredoxin.

Narin Changklungmoa et al.

Parasitology research, 113(6), 2335-2343 (2014-04-11)

In the present study, a cDNA encoding Trx from F. gigantica (FgTrx) was cloned by polymerase chain reaction (PCR). The sequence of FgTrx, analyzed by BLAST, SignalP, and ClustralW programs, showed 315 bp of an open reading frame (ORF), 12 bp 5'UTR

Ganoderma lucidum Polysaccharide Peptide Attenuates Skin Flap Ischemia-Reperfusion Injury in a Thioredoxin-Dependent Manner.

Huiwen Ren et al.

Plastic and reconstructive surgery, 142(1), 23e-33e (2018-04-13)

Thioredoxin-1 plays an important role in protecting the skin flap from ischemia-reperfusion injury. Ganoderma lucidum polysaccharide peptide is the major component of G. lucidum, which possesses potent antioxidant and antiapoptotic activity. This study aims to determine whether G. lucidum polysaccharide

查看所有相关文献

全球贸易项目编号

货号	GTIN
M5324-25MG	04061832722887
M5324-5MG	04061832722894