M5324
PX 12
≥98% (HPLC), powder
别名:
2-[(1-methylpropyl)dithio]-1H-imidazole
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关于此项目
经验公式（希尔记法）:
C7H12N2S2
化学文摘社编号:
分子量:
188.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
PX 12, ≥98% (HPLC), powder
InChI key
BPBPYQWMFCTCNG-UHFFFAOYSA-N
SMILES string
CCC(C)SSc1ncc[nH]1
InChI
1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)
assay
≥98% (HPLC)
form
powder
color
off-white to tan
solubility
DMSO: >25 mg/mL
storage temp.
2-8°C
Quality Level
相关类别
Application
PX 12 已被用作硫氧还蛋白 1 抑制剂前列腺癌细胞系，以分析其对细胞活力的影响。也曾作为缺氧诱导因子 (HIF)-1α抑制剂处理 H2228 细胞。
Biochem/physiol Actions
PX 12 是硫氧还蛋白抑制剂。
PX-12 抑制硫氧还蛋白氧化还原系统和 HIF-1a 活性。PX 12 抑制缺氧诱导的 HIF-1a 转录活性（IC50 11 nM）和 HT29 和 MCF-7 肿瘤细胞的增殖（IC50 分别为 1.9 和 0.9 μM）。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
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