M5435
6-Methyl-2-(phenylethynyl)pyridine hydrochloride
≥98% (HPLC)
Synonym(s):
MPEP hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C14H11N · HCl
CAS Number:
Molecular Weight:
229.70
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Product Name
6-Methyl-2-(phenylethynyl)pyridine hydrochloride, ≥98% (HPLC)
InChI
1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H
SMILES string
Cl.Cc1cccc(n1)C#Cc2ccccc2
InChI key
PKDHDJBNEKXCBI-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
off-white to light tan
solubility
DMSO: 10 mg/mL, clear
storage temp.
room temp
Quality Level
Gene Information
human ... GRIN2B(2904), GRM5(2915)
rat ... Grm5(24418)
Application
6-Methyl-2-(phenylethynyl)pyridine hydrochloride has been used to investigate whether 3, 4 (±) methylenedioxymethamphetamine (MDMA) could influence self-renewal via the mGlu5 receptor in mouse embryonic stem cells (mESCs).
Biochem/physiol Actions
GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B) plays an important role in the growth of neurons and is highly essential for learning and memory. GRIN2B mutation is associated with neuropsychiatric and developmental disorders like schizophrenia, Parkinson′s disease and bipolar disorder. MPEP (2-methyl-6-(phenylethynyl)pyridine hydrochloride) is used to treat Alzheimer′s disease (AD).
Highly selective, non-competitive mGluR5 metabotropic glutamate receptor antagonist.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
General description
GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B) codes for N-methyl d-aspartate receptor subtype 2B (GluN2B). It belongs to the N-methyl-D-aspartate receptor (NMDAR) gene family. It is located on chromosome 12p13.1.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Human GRIN2B variants in neurodevelopmental disorders
Hu C, et al.
Journal of Pharmacological Sciences, 132(2), 115-121 (2016)
Mélanie Cavalier et al.
Neurochemical research, 44(3), 609-616 (2018-01-22)
Maternal immune challenge has proved to induce moderate to severe behavioral disabilities in the offspring. Cognitive/behavioral deficits are supported by changes in synaptic plasticity in different brain areas. We have reported previously that prenatal exposure to bacterial LPS could induce
Geehoon Chung et al.
Scientific reports, 7(1), 9743-9743 (2017-08-31)
Patients with chronic pain easily accompany the negative mood symptoms such as depression and anxiety, and these disturbances in turn affect the aversive perception of pain. However, the underlying mechanisms are largely unknown. We hypothesized that the alteration of metabotropic
Li Rebekah Feng et al.
Translational psychiatry, 8(1), 110-110 (2018-06-01)
Cancer-related fatigue (CRF) is a common burden in cancer patients and little is known about its underlying mechanism. The primary aim of this study was to identify gene signatures predictive of post-radiotherapy fatigue in prostate cancer patients. We employed Fisher
José Luis Albasanz et al.
ACS chemical neuroscience, 7(12), 1690-1697 (2016-09-17)
Due to phylogenetic proximity to the human, zebrafish has been recognized as a reliable model to study Alzheimer's disease (AD) and other central nervous system disorders. Furthermore, metabotropic glutamate receptors have been previously reported to be impaired in brain from
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