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M5441

Mibefradil dihydrochloride hydrate

Name: Mibefradil dihydrochloride hydrate
Brand: SIGMA

≥98% (HPLC), powder, T-type Ca²⁺ channel blocker

Synonym(s):

(1S,2S)-2-[2[[3-(2-Benzimidazolyl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl methoxyacetate dihydrochloride hydrate, Ro 40-5967 hydrate

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About This Item

Empirical Formula (Hill Notation):

C₂₉H₃₈FN₃O₃ · 2HCl · xH₂O

CAS Number:

116666-63-8

Molecular Weight:

568.55 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

24278558

NACRES:

NA.77

MDL number:

MFCD11044451

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Product Name

Mibefradil dihydrochloride hydrate, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

H₂O: soluble >20 mg/mL, absolute ethanol: insoluble

originator

Roche

SMILES string

O.Cl.Cl.COCC(=O)O[C@]3(CCN(C)CCCc1nc2ccccc2[nH]1)CCc4cc(F)ccc4[C@@H]3C(C)C

InChI

1S/C29H38FN3O3.2ClH.H2O/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26;;;/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32);2*1H;1H2/t28-,29-;;;/m0.../s1

InChI key

IZSWBBGKLWFDOC-YKXHUFBBSA-N

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

Mibefradil has been used as a T-type calcium channel blocker in various cells. It has also been used to reduce apoptosis of retinal ganglion cells (RGC) in EphB2-Fc.

Biochem/physiol Actions

Mibefradil is a tetralol derivative and nondihydropyridine calcium channel blocker. It blocks long-type (L-type) calcium channels. It blocks mildly the Purkinje-type (P-type) calcium channels in Purkinje neurons.

Ro 40-5967 is a T-type Ca²⁺ channel blocker; antihypertensive.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Mibefradil inhibition of T-type calcium channels in cerebellar purkinje neurons

McDonough S I and Bean B P

Molecular Pharmacology, 54(6), 1080-1087 (1998)

Mibefradil block of cloned T-type calcium channels

Martin R L, et al.

Journal of Pharmacology and Experimental Therapeutics, 295(1), 302-308 (2000)

On the origin of rhythmic calcium transients in the ICC-MP of the mouse small intestine.

Bobbi-Jo Lowie et al.

American journal of physiology. Gastrointestinal and liver physiology, 301(5), G835-G845 (2011-08-13)

Interstitial cells of Cajal associated with the myenteric plexus (ICC-MP) are pacemaker cells of the small intestine, producing the characteristic omnipresent electrical slow waves, which orchestrate peristaltic motor activity and are associated with rhythmic intracellular calcium oscillations. Our objective was

Calcium channels are involved in EphB/ephrinB reverse signaling-induced apoptosis in a rat chronic ocular hypertension model

Dong L, et al.

Molecular Medicine Reports, 17(2), 2465-2471 (2018)

The sound of silence: ionic mechanisms encoding sound termination.

Cornelia Kopp-Scheinpflug et al.

Neuron, 71(5), 911-925 (2011-09-10)

Offset responses upon termination of a stimulus are crucial for perceptual grouping and gap detection. These gaps are key features of vocal communication, but an ionic mechanism capable of generating fast offsets from auditory stimuli has proven elusive. Offset firing

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Global Trade Item Number

SKU	GTIN
M5441-25MG	04061834059967
M5441-5MG	04061834059974

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