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M5793

3-Morpholinosydnonimine hydrochloride

Name: 3-Morpholinosydnonimine hydrochloride
Brand: SIGMA

guanylyl cyclase activator

Synonym(s):

3-(4-Morpholinyl)sydnone imine hydrochloride, Linsidomine hydrochloride, SIN-1 hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₆H₁₀N₄O₂ · HCl

CAS Number:

16142-27-1

Molecular Weight:

206.63

UNSPSC Code:

12352200

PubChem Substance ID:

24897048

NACRES:

NA.77

MDL number:

MFCD00214332

Quality level:

200

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Product Name

3-Morpholinosydnonimine hydrochloride, (consistent with structure, NMR)

Quality Level

200

storage temp.

−20°C

SMILES string

Cl[H].[NH-]c1c[n+](no1)N2CCOCC2

InChI

1S/C6H10N4O2.ClH/c7-6-5-10(8-12-6)9-1-3-11-4-2-9;/h5,7H,1-4H2;1H

InChI key

NCGICGYLBXGBGN-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

3-Morpholinosydnonimine hydrochloride has been used:

as a peroxynitrite donor standard to study the accumulation of peroxynitrite in Arabidopsis thaliana
to study its effects on nitrosative stress in human brain vascular pericytes and human embryonic kidney cells
as a ROS to study its effects on mouse embryonic fibroblasts

Biochem/physiol Actions

3-Morpholinosydnonimine participates in the inhibition of cysteine proteases.

Liberates nitric oxide (NO) spontaneously when in solution, activating guanylyl cyclase and causing an increase in cyclic-GMP. This product is a vasodilator and inhibits platelet aggregation. Using molecular oxygen, it generates both superoxide anion and nitric oxide that spontaneously form peroxynitrite.

Liberates nitric oxide (NO) spontaneously when in solution, activating guanylyl cyclase and causing an increase in cyclic-GMP; vasodilator.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000458780

0000404431

0000389762

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The Free Radical Scavenging and Anti-Isolated Human LDL Oxidation Activities of Pluchea indica (L.) Less. Tea Compared to Green Tea (Camellia sinensis).

Kittipot Sirichaiwetchakoon et al.

BioMed research international, 2020, 4183643-4183643 (2020-10-09)

Tea is one of the most popular beverages in the world. Camellia sinensis tea (CST) or green tea is widely regarded as a potent antioxidant. In Thailand, Pluchea indica (L.) Less. tea (PIT) has been commercially available as a health-promoting

Detection of peroxynitrite accumulation in Arabidopsis thaliana during the hypersensitive defense response.

Frank Gaupels et al.

Nitric oxide : biology and chemistry, 25(2), 222-228 (2011-02-08)

Nitric oxide (NO) is synthesized in plants in response to stress, and its role in signaling is well-documented. In contrast, very little is known about the physiological role of its derivate peroxynitrite (ONOO(-)), which forms when NO reacts with O(2)(-)

Ladostigil Attenuates Induced Oxidative Stress in Human Neuroblast-like SH-SY5Y Cells.

Keren Zohar et al.

Biomedicines, 9(9) (2021-09-29)

A hallmark of the aging brain is the robust inflammation mediated by microglial activation. Pathophysiology of common neurodegenerative diseases involves oxidative stress and neuroinflammation. Chronic treatment of aging rats by ladostigil, a compound with antioxidant and anti-inflammatory function, prevented microglial

Inhibition of cysteine protease activity by NO-donors.

P Ascenzi et al.

Current protein & peptide science, 2(2), 137-153 (2002-10-09)

Cysteine proteases represent a broad class of proteolytic enzymes widely distributed among living organisms. Although well known as typical lysosomal enzymes, cysteine proteases are actually recognized as multi-function enzymes, being involved in antigen processing and presentation, in membrane-bound protein cleavage

Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice.

Tangying Lu et al.

The Journal of clinical investigation, 121(10), 4015-4029 (2011-09-14)

Cancer immunotherapeutic approaches induce tumor-specific immune responses, in particular CTL responses, in many patients treated. However, such approaches are clinically beneficial to only a few patients. We set out to investigate one possible explanation for the failure of CTLs to

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Sensor Dyes

Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

感应染料

一氧化氮 (NO) 是神经元、内皮细胞和免疫系统中的信号转运分子。

Global Trade Item Number

SKU	GTIN
M5793-100MG	04061834060369
M5793-25MG	04061834060376

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