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Merck
CN

M6013

Medroxyprogesterone

Synonym(s):

17α-Hydroxy-6α-methyl-4-pregnene-3,20-dione, 17α-Hydroxy-6α-methylprogesterone, 6α-Methyl-5-pregnen-17α-ol-3,20-dione, 6-Dihydromegestrol

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About This Item

Empirical Formula (Hill Notation):
C22H32O3
CAS Number:
520-85-4
Molecular Weight:
344.49
UNSPSC Code:
51111800
NACRES:
NA.77
PubChem Substance ID:
24897065
EC Number:
208-298-6
Beilstein/REAXYS Number:
2510965
MDL number:
MFCD00069474
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥98% (HPLC)

Key Documents

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InChI key

FRQMUZJSZHZSGN-HBNHAYAOSA-N

InChI

1S/C22H32O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18(16)7-10-22(21,25)14(2)23/h12-13,16-18,25H,5-11H2,1-4H3/t13-,16+,17-,18-,20+,21-,22-/m0/s1

SMILES string

[H][C@@]12C[C@H](C)C3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(C)=O

biological source

synthetic (organic)

assay

≥98% (HPLC)

form

powder

solubility

chloroform: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

Quality Level

100

Gene Information

rat ... Ar(24208)

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Disclaimer

Much of the pharmacology literature refers to medroxyprogesterone acetate as medroxyprogesterone, but they are of course not the same substance.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361fd

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
MKCV0339
MKCQ7743
MKCN7824
MKCN7079
MKCC5370

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Adarsh J Sai et al.
Menopause (New York, N.Y.), 18(10), 1101-1112 (2011-06-30)
The aim of this study was to examine the effect of conjugated equine estrogens alone (ET), conjugated equine estrogens + medroxyprogesterone (EPT), calcitriol alone, calcitriol + EPT/ET, or placebo on serum lipid profile and analyze the interaction with estrogen receptor-α
M F Fung et al.
Obstetrics and gynecology, 78(6), 1033-1038 (1991-12-01)
We conducted a retrospective review of 44 patients with metastatic or recurrent endometrial carcinoma treated with cisplatin, doxorubicin, cyclophosphamide, and medroxyprogesterone acetate. Thirty-six women had metastatic disease; eight had recurrent disease. In the metastatic group, 12 women had positive peritoneal
Clinical significance of differences in bioavailability of medroxyprogesterone acetate preparations.
A D Stockdale et al.
Clinical pharmacokinetics, 16(3), 129-133 (1989-03-01)
The role of medroxyprogesterone acetate (MPA) in the treatment of renal adenocarcinoma.
M Kjaer
Cancer treatment reviews, 15(3), 195-209 (1988-09-01)
A Günzel-Apel et al.
Reproduction in domestic animals = Zuchthygiene, 47 Suppl 6, 55-60 (2013-01-04)
Progesterone profiles of individual bitches may vary considerably both between and within individuals during pregnancy and non-pregnancy. Suspected luteal deficiency is commonly purported but is difficult to evaluate in clinical cases when progesterone is supplemented because this masks the underlying
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