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M6316

MRS 1754 hydrate

Name: MRS 1754 hydrate
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₂₆N₆O₄ · xH₂O

CAS Number:

264622-58-4

Molecular Weight:

486.52 (anhydrous basis)

UNSPSC Code:

12352200

NACRES:

NA.77

PubChem Substance ID:

24278793

MDL number:

MFCD11046004

Assay:

≥98% (HPLC)

Form:

solid

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: soluble >10 mg/mL

storage temp.

room temp

SMILES string

O.CCCN1C(=O)N(CCC)c2[nH]c(nc2C1=O)-c3ccc(OCC(=O)Nc4ccc(cc4)C#N)cc3

InChI

1S/C26H26N6O4.H2O/c1-3-13-31-24-22(25(34)32(14-4-2)26(31)35)29-23(30-24)18-7-11-20(12-8-18)36-16-21(33)28-19-9-5-17(15-27)6-10-19;/h5-12H,3-4,13-14,16H2,1-2H3,(H,28,33)(H,29,30);1H2

InChI key

ZACJDWOPQROWIK-UHFFFAOYSA-N

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora2b(29316)

Description

Application

MRS 1754 hydrate has been used as an adenosine receptor A2B (RA2B) antagonist:

to study its effects on endothelial nitric oxide synthase (eNOS) phosphorylation induced by short-term acetate stimulation in human umbilical vein endothelial cells (HUVECs)
blastema formation in zebrafish
to serve as a positive control in the anti-sickling assay and to study the role of RA2B in the same

Biochem/physiol Actions

MRS 1754 hydrate is a p-cyanoanilide xanthine derivative. It might act as a potential anti-asthmatic drug.

MRS 1754 hydrate is a potent A_2B adenosine receptor antagonist.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Manufactured and sold under license from Adenosine Therapeutics LLC.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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