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M7008

4-Methylumbelliferyl-β-D-xylopyranoside

Name: 4-Methylumbelliferyl-&#946;-<SC>D</SC>-xylopyranoside
Brand: SIGMA

β-xylosidase substrate, fluorogenic, ≥98% (HPLC), powder

Synonym(s):

4-Methylumbelliferyl β-D-xyloside

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₆O₇

CAS Number:

6734-33-4

Molecular Weight:

308.28

NACRES:

NA.32

PubChem Substance ID:

24897133

UNSPSC Code:

12352204

EC Number:

229-784-4

MDL number:

MFCD00037607

Beilstein/REAXYS Number:

39934

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Product Name

4-Methylumbelliferyl-β-D-xylopyranoside, β-xylosidase substrate

Quality Level

200

assay

≥98% (HPLC)

form

powder

solubility

pyridine: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

CC1=CC(=O)Oc2cc(O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)ccc12

InChI

1S/C15H16O7/c1-7-4-12(17)22-11-5-8(2-3-9(7)11)21-15-14(19)13(18)10(16)6-20-15/h2-5,10,13-16,18-19H,6H2,1H3/t10-,13+,14-,15+/m1/s1

InChI key

JWIYLOHVJDJZOQ-KAOXEZKKSA-N

General description

A substrate for β-xylosidase

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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Alterations of matrix- and cell-associated proteoglycans inhibit osteogenesis and growth response to fibroblast growth factor-2 in cultured rat mandibular condyle and calvaria.

A Molténi et al.

Cell and tissue research, 295(3), 523-536 (1999-02-18)

Matrix and cell surface proteoglycans (PGs) may play important roles in the control of cellular actions of heparan-binding growth factors such as fibroblast growth factor (FGF) during chondrogenesis and osteogenesis. In this study, we used 4-methylumbelliferyl-beta-d-xyloside, an inhibitor of PG

Regulation of heparan sulfate and chondroitin sulfate glycosaminoglycan biosynthesis by 4-fluoro-glucosamine in murine airway smooth muscle cells.

Julie Nigro et al.

The Journal of biological chemistry, 284(25), 16832-16839 (2009-04-07)

The importance of the pathological changes in proteoglycans has driven the need to study and design novel chemical tools to control proteoglycan synthesis. Accordingly, we tested the fluorinated analogue of glucosamine (4-fluoro-N-acetyl-glucosamine (4-F-GlcNAc)) on the synthesis of heparan sulfate (HS)

A novel oligosaccharide, GlcA beta 1-4Xyl beta 1-(4-methylumbelliferone), synthesized by human cultured skin fibroblasts.

T Nakamura et al.

The Biochemical journal, 304 ( Pt 3), 731-736 (1994-12-15)

Human skin fibroblasts were cultured in the presence of 4-methylumbelliferyl-beta-D-xyloside (Xyl-MU) using a mass-culture system with a microcarrier. The structures of Xyl-MU-induced sugars purified from the dialysable fraction of the incubation medium were investigated. In addition to glycosaminoglycans the elongation

Characterization of beta-D-xyloside-induced glycosaminoglycans and oligosaccharides in cultured human skin fibroblasts.

K Takagaki et al.

Journal of biochemistry, 109(4), 514-519 (1991-04-01)

Human skin fibroblasts were incubated in the presence of a fluorogenic xyloside, 4-methylumbelliferyl beta-D-xyloside. Three fluorogenic components were isolated and purified from the culture medium by gel permeation high-performance liquid chromatography. Their structures were then characterized by enzymatic digestion, fast-atom-bombardment

HNK-1-reactive novel oligosaccharide, sulfate-O-3GlcA beta 1-4Xyl beta 1-(4-methylumbelliferone), synthesized by cultured human skin fibroblasts.

S Shibata et al.

The Journal of biological chemistry, 270(23), 13794-13798 (1995-06-09)

4-Methylumbelliferyl-beta-D-xyloside (Xyl-MU) was added to the medium of cultured human skin fibroblasts. After incubation, the culture medium was pooled, and the Xyl-MU-induced oligosaccharides in the medium were purified by gel filtration chromatography. A novel Xyl-MU derivative was obtained, in addition

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Global Trade Item Number

SKU	GTIN
M7008-1G	04061826691748
M7008-25MG	04061834061472
M7008-100MG	04061832909257
M7008-250MG	04061832909264

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