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M7133

4-Methylumbelliferyl sulfate potassium salt

Name: 4-Methylumbelliferyl sulfate potassium salt
Brand: SIGMA

sulfatase substrate

Synonym(s):

Potassium 4-methylumbelliferyl sulfate

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₇KO₆S

CAS Number:

15220-11-8

Molecular Weight:

294.32

UNSPSC Code:

12352204

NACRES:

NA.32

PubChem Substance ID:

24897141

EC Number:

239-272-2

Beilstein/REAXYS Number:

3803203

MDL number:

MFCD00016970

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Properties

Quality Segment

200

assay

≥99% (HPLC)

form

powder

solubility

water: 5 mg/mL, clear, colorless

fluorescence

λ_ex 334 nm; λ_em 370 nm (pH 10.4), λ_ex 360 nm; λ_em 449 nm (Reaction products)

storage temp.

−20°C

SMILES string

[K+].CC1=CC(=O)Oc2cc(OS([O-])(=O)=O)ccc12

InChI

1S/C10H8O6S.K/c1-6-4-10(11)15-9-5-7(2-3-8(6)9)16-17(12,13)14;/h2-5H,1H3,(H,12,13,14);/q;+1/p-1

InChI key

CSOCSPXOODWGLJ-UHFFFAOYSA-M

Description

General description

4-Methylumbelliferyl sulfate (4MUS), a general substrate, is a polar metabolite of 4-methylumbelliferone (4MU).

Application

4-Methylumbelliferyl sulfate potassium salt has been used as a substrate in coupled fluorescence sulfotransferase assay to regenerate 3′-phosphoadenosine 5′-phosphosulfate (PAPS) from 3′-phosphoadenosine 5′-phosphate for cerebroside sulfotransferase (CST) enzyme activity measurements. It has also been used as a substrate in arylsulfatase assay/4-methylumbelliferyl sulfate (4-MUS) assay to test the enzymatic activity of the protein-bead complex.

Biochem/physiol Actions

4-Methylumbelliferyl sulfate (4MUS) is capable of undergoing desulfation and involve in futile cycling with 4MU. It can be utilized to measure the arylsulfatase activity of several sulfatases.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

Drug Conjugate Analysis using β-Glucuronidases

Drug conjugate analysis and the enzymatic hydrolysis of glucuronides

Global Trade Item Number

SKU	GTIN
M7133-1G	04061834061649
M7133-500MG	04061834061656