M7133
4-Methylumbelliferyl sulfate potassium salt
sulfatase substrate
Synonym(s):
Potassium 4-methylumbelliferyl sulfate
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About This Item
Empirical Formula (Hill Notation):
C10H7KO6S
CAS Number:
Molecular Weight:
294.32
UNSPSC Code:
12352204
NACRES:
NA.32
PubChem Substance ID:
EC Number:
239-272-2
Beilstein/REAXYS Number:
3803203
MDL number:
Quality Level
assay
≥99% (HPLC)
form
powder
solubility
water: 5 mg/mL, clear, colorless
fluorescence
λex 334 nm; λem 370 nm (pH 10.4), λex 360 nm; λem 449 nm (Reaction products)
storage temp.
−20°C
SMILES string
[K+].CC1=CC(=O)Oc2cc(OS([O-])(=O)=O)ccc12
InChI
1S/C10H8O6S.K/c1-6-4-10(11)15-9-5-7(2-3-8(6)9)16-17(12,13)14;/h2-5H,1H3,(H,12,13,14);/q;+1/p-1
InChI key
CSOCSPXOODWGLJ-UHFFFAOYSA-M
General description
4-Methylumbelliferyl sulfate (4MUS), a general substrate, is a polar metabolite of 4-methylumbelliferone (4MU).
Application
4-Methylumbelliferyl sulfate potassium salt has been used as a substrate in coupled fluorescence sulfotransferase assay to regenerate 3′-phosphoadenosine 5′-phosphosulfate (PAPS) from 3′-phosphoadenosine 5′-phosphate for cerebroside sulfotransferase (CST) enzyme activity measurements. It has also been used as a substrate in arylsulfatase assay/4-methylumbelliferyl sulfate (4-MUS) assay to test the enzymatic activity of the protein-bead complex.
Biochem/physiol Actions
4-Methylumbelliferyl sulfate (4MUS) is capable of undergoing desulfation and involve in futile cycling with 4MU. It can be utilized to measure the arylsulfatase activity of several sulfatases.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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O P van Diggelen et al.
Journal of inherited metabolic disease, 12(3), 273-280 (1989-01-01)
Arylsulphatase C (ASC) activity in leukocytes and fibroblasts measured with 4-methylumbelliferylsulphate, is caused by at least two genetically different sulphatases. One of these is steroid sulphatase (STS). Depending on the substrate concentration, about 10-50% of the ASC activity in leukocytes
A M Hassen et al.
Drug metabolism and disposition: the biological fate of chemicals, 24(7), 792-798 (1996-07-01)
The uptake of estrone sulfate (E1S; 1 to 400 microM), harmol sulfate (HS; 5 to 900 microM), and 4-methylumbelliferyl sulfate (4MUS; 5 to 1000 microM) was investigated in isolated rat hepatocytes in the presence or absence of inhibitors. Uptake of
C L Zimmerman et al.
Journal of chromatography, 563(1), 83-94 (1991-01-18)
A direct high-performance liquid chromatographic (HPLC) assay was developed for the separation and determination of 4-methylumbelliferone (4MU) and its glucuronide (MUG) and sulfate (MUS) conjugates in the cell-free perfusate ("plasma") from in situ perfused rat intestine-liver preparation. In addition, a
Junichi Enokizono et al.
Drug metabolism and disposition: the biological fate of chemicals, 35(6), 922-928 (2007-03-14)
Breast cancer resistance protein (Bcrp/Abcg2) is a member of the ATP-binding cassette transporter family with the ability to transport a variety of sulfate conjugates. In the present study, the regional expression and activity of Bcrp and sulfotransferases (SULTs/Sults) were investigated
P M Edelbroek et al.
Journal of chromatography, 530(2), 347-358 (1990-09-14)
The anticoagulant phenprocoumon is mainly metabolized in humans to hydroxylated metabolites and their glucuronides. A method is described for the determination of phenprocoumon, 4'-hydroxyphenprocoumon, 6-hydroxyphenprocoumon, 7-hydroxyphenprocoumon, and their glucuronide and sulphate conjugates in human urine. Reversed-phase high-performance liquid chromatography is
Articles
Drug conjugate analysis and the enzymatic hydrolysis of glucuronides
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M7133-1G | 04061834061649 |
| M7133-500MG | 04061834061656 |
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