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M8449

MAN-5 Glycan

≥90% (HPLC)

Synonym(s):

(Man)5(GlcNAc)2, Mannopentaose-di-(N-acetyl-D-glucosamine), Oligomannose-5 glycan

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About This Item

Empirical Formula (Hill Notation):
C46H78N2O36
CAS Number:
66091-47-2
Molecular Weight:
1235.10
NACRES:
NA.25
PubChem Substance ID:
329818060
UNSPSC Code:
12352201
MDL number:
MFCD00467030
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Quality Level

200

assay

≥90% (HPLC)

form

solid

storage temp.

−20°C

SMILES string

CC(=O)NC(C=O)C(O)C(OC1OC(CO)C(OC2OC(COC3OC(COC4OC(CO)C(O)C(O)C4O)C(O)C(OC5OC(CO)C(O)C(O)C5O)C3O)C(O)C(OC6OC(CO)C(O)C(O)C6O)C2O)C(O)C1NC(C)=O)C(O)CO

InChI

1S/C46H78N2O36/c1-11(55)47-13(3-49)22(58)37(14(57)4-50)81-41-21(48-12(2)56)28(64)38(18(8-54)78-41)82-46-36(72)40(84-45-34(70)31(67)25(61)17(7-53)77-45)27(63)20(80-46)10-74-43-35(71)39(83-44-33(69)30(66)24(60)16(6-52)76-44)26(62)19(79-43)9-73-42-32(68)29(65)23(59)15(5-51)75-42/h3,13-46,50-54,57-72H,4-10H2,1-2H3,(H,47,55)(H,48,56)

InChI key

KIAGZJJOMMNKBW-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

Antibodies bearing high levels of N-linked mannose-5 glycan (Man-5) have been found to exhibit enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) when compared to antibodies with fucosylated complex or hybrid glycans.
Antibodies carrying high levels of N-linked mannose-5 glycan (Man5) possesses increased antibody-dependent cell-mediated cytotoxicity (ADCC) than antibodies with fucosylated complex or hybrid glycans.

Other Notes

To gain a comprehensive understanding of our extensive range of Oligosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000481136
0000481136
0000465330
0000465330
0000322707

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Marcella Yu et al.
mAbs, 4(4), 475-487 (2012-06-16)
The effector functions of therapeutic antibodies are strongly affected by the specific glycans added to the Fc domain during post-translational processing. Antibodies bearing high levels of N-linked mannose-5 glycan (Man5) have been reported to exhibit enhanced antibody-dependent cell-mediated cytotoxicity (ADCC)

Global Trade Item Number

SKUGTIN
M8449-10UG04061833247495

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