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Merck
CN

M8543

Monocyte Chemotactic Protein-3 human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

MCP-3

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About This Item

UNSPSC Code:
51111800
PubChem Substance ID:
24897273
MDL number:
MFCD01094591

Key Documents

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InChI

1S/C62H104N4O46/c1-15(76)63-19(5-67)32(81)48(20(80)6-68)106-55-29(64-16(2)77)38(87)51(27(13-75)102-55)109-60-47(96)52(110-62-54(44(93)36(85)24(10-72)101-62)112-57-31(66-18(4)79)40(89)50(26(12-74)104-57)108-59-46(95)42(91)34(83)22(8-70)99-59)37(86)28(105-60)14-97-61-53(43(92)35(84)23(9-71)100-61)111-56-30(65-17(3)78)39(88)49(25(11-73)103-56)107-58-45(94)41(90)33(82)21(7-69)98-58/h5,19-62,68-75,80-96H,6-14H2,1-4H3,(H,63,76)(H,64,77)(H,65,78)(H,66,79)

SMILES string

CC(=O)NC(C=O)C(O)C(OC1OC(CO)C(OC2OC(COC3OC(CO)C(O)C(O)C3OC4OC(CO)C(OC5OC(CO)C(O)C(O)C5O)C(O)C4NC(C)=O)C(O)C(OC6OC(CO)C(O)C(O)C6OC7OC(CO)C(OC8OC(CO)C(O)C(O)C8O)C(O)C7NC(C)=O)C2O)C(O)C1NC(C)=O)C(O)CO

InChI key

JMUPMJGUKXYCMF-UHFFFAOYSA-N

biological source

human

recombinant

expressed in E. coli

assay

≥97% (SDS-PAGE)

form

lyophilized powder

mol wt

9000 kDa

packaging

pkg of 10 μg

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P80098

storage temp.

−20°C

Quality Level

200

Gene Information

human ... CCL7(6354)

Physical form

Lyophilized from 30% acetonitrile and 0.1% trifluoroacetic acid containing 50 μg bovine serum albumin per 1 μg of cytokine.

Analysis Note

The biological activity is measured by its ability to chemoattract mouse BaF/3 cells transfected with human CCR2A.

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
115K1215
075K1133
093K1417
090K1078
122K0523

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G Opdenakker et al.
Biochemical and biophysical research communications, 191(2), 535-542 (1993-03-15)
When human MG-63 osteosarcoma cells are triggered with IL-1 beta, they produce, among various other cytokines, also monocyte chemotactic proteins (MCPs). Homogeneous MCP-1, MCP-2 and MCP-3 were found to induce production of gelatinase B and chemotaxis of monocytes. Based on
A Ben-Baruch et al.
The Journal of biological chemistry, 270(38), 22123-22128 (1995-09-22)
Monocyte chemotactic protein-3 (MCP3) is recently identified and molecularly cloned C-C chemokine that is chemotactic for and activates a great variety of inflammatory cell types. MCP3 has been reported to interact with several C-C chemokine receptors, which can be simultaneously
M Weber et al.
Journal of immunology (Baltimore, Md. : 1950), 154(8), 4166-4172 (1995-04-15)
It has been shown that CC chemokines activate basophil and eosinophil leukocytes with different selectivities and patterns of activity. The most effective are monocyte chemotactic protein-1 (MCP-1), a potent stimulus of mediator release in basophils without effects on eosinophils, RANTES

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