M8816
Microsomes from Liver, Pooled
from Monkey(Cynomolgus spp.), male
Synonym(s):
lab equipment accessory
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About This Item
NACRES:
NB.35
UNSPSC Code:
12161501
Specific activity:
≥5000 units/mg protein
Biological source:
Monkey (Cynomolgus spp.)
biological source
Monkey (Cynomolgus spp.)
form
liquid
specific activity
≥5000 units/mg protein
packaging
vial of ~10 mg
shipped in
dry ice
storage temp.
−70°C
Application
Microsomes from Liver, Pooled has been used to measure the in vitro stabilities of the prodrugs. It has also been used in microsomal incubation to generate BTX-3 metabolites to serve as references for liquid chromatography with tandem mass spectrometry (LC-MS/MS) analyses of urine.
Biochem/physiol Actions
Microsomal cytochrome P450 proteins can catalyze the transfer of a single oxygen atom to endogenous and exogenous compounds, like steroids and phenobarbital, meant for excretion and detoxification.
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
Source of drug metabolizing enzymes, including cytochrome P-450.
Other Notes
One unit will produce 1.0 picomole of 6 beta-hydroxytestosterone per minute at pH 7.4 at 37 deg C.
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Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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