M8948
Monoclonal Anti-Myocardin antibody produced in mouse
~2.0 mg/mL, clone MCR54, purified immunoglobulin
Synonym(s):
Anti-MYCD, Anti-MYOCD
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Product Name
Monoclonal Anti-Myocardin antibody produced in mouse, ~2.0 mg/mL, clone MCR54, purified immunoglobulin
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
MCR54, monoclonal
form
buffered aqueous solution
mol wt
antigen ~150 kDa
species reactivity
human
packaging
antibody small pack of 25 μL
concentration
~2.0 mg/mL
technique(s)
western blot: 2.5-5 μg/mL using HEK-293T cells overexpressing myocardin
isotype
IgG2b
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MYOCD(93649)
Application
Monoclonal Anti-Myocardin antibody produced in mouse has been used in western blot analysisimmunofluorescence.
Biochem/physiol Actions
Myocardin (MYOCD) takes part in the differentiation of vascular smooth muscle cells (VSMC). It is a co-factor of serum response factor (SRF) and regulates the activation of those genes which are dependent on SRF. MYOCD forms a complex with SRF on DNA.
Myocardin is a smooth and cardiac muscle-specific transcriptional coactivator of serum response factor (SRF). It regulates the expression of a set of cardiac and smooth muscle-specific genes. Myocardin was implicated in the pathogenesis of atherosclerosis, Alzheimer′s disease, and malignant transformation.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-Myocardin (mouse IgG2b isotype) is derived from the hybridoma MCR54 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human myocardin. Myocardin (MYOCD) is a transcriptional coactivator.
Myocardin (MYOCD) is expressed in the muscles and cardiomyocytes. It is a co-transcriptional factor.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
Regulatory Information
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Pavneet Singh et al.
PloS one, 9(11), e112120-e112120 (2014-11-11)
De-differentiation of vascular smooth muscle cells (VSMCs) plays a critical role in the development of atherosclerosis, a chronic inflammatory disease involving various cytokines such as tumor necrosis factor-α (TNFα). Myocardin is a co-factor of serum response factor (SRF) and is
Myocardin in biology and disease
Miano JM
Journal of biomedical research, 29(1), 3-3 (2015)
The serum response factor coactivator myocardin is required for vascular smooth muscle development
Li S, et al.
Proceedings of the National Academy of Sciences of the USA, 100(16), 9366-9370 (2003)
Fibroblast growth factor 12 is a novel regulator of vascular smooth muscle cell plasticity and fate
Song SH, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 36(9), 1928-1936 (2016)
Linda Raphel et al.
PloS one, 7(8), e44052-e44052 (2012-09-01)
Myocardin is thought to have a key role in smooth muscle cell (SMC) development by acting on CArG-dependent genes. However, it is unclear whether myocardin-induced SMC maturation and increases in agonist-induced calcium signalling are also associated with increases in the
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