M9695
Matrix Metalloproteinase-12, Catalytic Domain human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
MMP-12, Macrophage Elastase
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About This Item
recombinant
expressed in E. coli
Quality Segment
assay
≥95% (SDS-PAGE)
form
buffered aqueous glycerol solution
mol wt
calculated mol wt 20.3 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... MMP12(4321)
General description
Matrix metalloproteinase-12 (MMP-12) is also called as macrophage metalloelastase and is secreted by inflammatory macrophages. It is synthesized as a zymogen and then activated by cleaving the propeptide domain. The MMP-12 gene is localized on chromosome 11.
Biochem/physiol Actions
MMP-12 degrades general matrix components and may have a role in processes such as host defense, cell proliferation, and protein turnover as well as tissue remodeling.
Matrix metalloproteinase-12 (MMP-12) breaks down proteoglycans, collagen type IV and laminin. Its main substrate is elastin.
Physical form
Solution in 50 mM Tris, 5 mM calcium chloride, 500 mM sodium chloride, 20 μM zinc chloride, 0.5% Brij® L23, and 30% glycerol, pH 9.5.
Other Notes
One unit equals 100 pmol/min at 37 °C using the colorimetric thiopeptolide Ac-Pro-Leu-Gly-S-Leu-Leu-Gly-OEt as substrate.
Legal Information
Brij is a registered trademark of Croda International PLC
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 3
Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Gloves, multi-purpose combination respirator cartridge (US)
wgk
WGK 3
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