MAK005
Phenylalanine Assay Kit
sufficient for 100 fluorometric tests
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About This Item
NACRES:
NA.84
UNSPSC Code:
12161503
Product Name
Phenylalanine Assay Kit, sufficient for 100 fluorometric tests
usage
sufficient for 100 fluorometric tests
detection method
fluorometric
relevant disease(s)
neonatal diseases; neurological disorders; pediatric diseases
storage temp.
−20°C
Application
Suitable for L-phenylalanine detection in cell and tissue culture supernatants, serum, and other biological samples
Biochem/physiol Actions
Phenylalanine concentration is determined by a coupled enzyme assay, which results in the deamination of phenylalanine and the production of NADH which reacts with the probe resulting in a fluorescent (λex = 535 nm/λem = 587 nm) product, proportional to the phenylalanine present.
General description
Phenylalanine is a non-polar essential amino acid. In the liver, phenylalanine is converted to tyrosine, which is a precursor for multiple compounds including L-DOPA and melanin. Defects in the activity of phenylalanine hydroxylase result in the inherited metabolic disorder phenylketonuria (PKU). PKU results in the build up of phenylalanine and phenylalanine metabolites, and can result in growth defects and mental retardation if not treated.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
10 - Combustible liquids
flash_point_f
No data available
flash_point_c
No data available
Regulatory Information
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Nathan Crook et al.
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AMINO ACIDS | Metabolism
Encyclopedia of Food Sciences and Nutrition (Second Edition) (2003)
Phenylketonuria: an inborn error of phenylalanine metabolism.
Williams R A, et al.
The Clinical Biochemist. Reviews / Australian Association of Clinical Biochemists, 29(1), 31-31 (2008)
Protein and Amino Acid Metabolism
Essentials of Medical Biochemistry null
CTI Reviews
Clinical Chemistry, Principles, Procedures, Correlations (2016)
Protocols
Assay protocol for the fluorometric detection of Phenylalanine in biological samples using the phenylalanine assay kit.
Related Content
Instructions
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