MAK036
Hemin Assay Kit
sufficient for 100 colorimetric tests
Synonym(s):
Hemin Quantitative Test Kit
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About This Item
NACRES:
NA.84
UNSPSC Code:
12161503
usage
sufficient for 100 colorimetric tests
application(s)
cosmetics
food and beverages
detection method
colorimetric
relevant disease(s)
immunological diseases; rheumatological diseases; gastrointestinal diseases; cardiovascular diseases
storage temp.
2-8°C
General description
Hemin, the oxidized version of heme, is an iron-containing prosthetic group for a diverse group of proteins. Free heme, which can be released from hemoglobin following hemolysis, is pro-inflammatory and contributes to iron-derived reactive oxygen species. Free hemin levels may be upregulated in various pathological conditions and can contribute to various inflammatory conditions including vascular disorders, renal failure, and immune-mediated disorders.
Application
Hemin Assay Kit has been used to determine the level of free hemin (oxidized heme).
Suitable for use with cell and tissue culture supernatants, urine, plasma, serum, fecal material, media, and other biological fluids.
Biochem/physiol Actions
In this assay, Hemin concentration is determined by a coupled enzyme reaction, which results in a colorimetric (570 nm) product, proportional to the Hemin present.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
10 - Combustible liquids
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
Regulatory Information
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Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity.
Fader K A, et al.
Toxicology and Applied Pharmacology, 321, 1-17 (2017)
Characterization of novel inhibition of indoleamine 2, 3-dioxygenase by targeting its apo form.
Ortiz-Meoz R F, et al.
bioRxiv, 324947-324947 (2018)
Danilo Grünig Humberto da Silva et al.
Toxicology in vitro : an international journal published in association with BIBRA, 56, 62-74 (2019-01-18)
This study investigated the effects of incubation period and melatonin treatment on red blood cell (RBC) metabolism in an auto-incubation model of H2O2-induced oxidative stress. The study was carried out on three healthy adult donors by incubating RBCs in their
Solid phase extraction of hemin from serum of breast cancer patients using an ionic liquid coated Fe3O4/graphene oxide nanocomposite, and its quantitation by using FAAS.
Farzin L, et al.
Microchimica Acta, 183(9), 2623-2631 (2016)
Kelly A Fader et al.
Toxicology and applied pharmacology, 321, 1-17 (2017-02-19)
Persistent aryl hydrocarbon receptor (AhR) agonists elicit dose-dependent hepatic lipid accumulation, oxidative stress, inflammation, and fibrosis in mice. Iron (Fe) promotes AhR-mediated oxidative stress by catalyzing reactive oxygen species (ROS) production. To further characterize the role of Fe in AhR-mediated
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