MSST0036
SILu™Lite CCL2 C-C motif chemokine 2 human
recombinant, expressed in HEK 293 cells, MS Protein Standard
Synonym(s):
HC11, Monocyte chemoattractant protein 1, Monocyte chemotactic protein 1(MCP-1), Monocyte secretory protein JE, Monocytechemoattractantprotein1, Monocytechemotacticandactivatingfactor(MCAF), Small-inducible cytokine A2
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About This Item
NACRES:
NA.12
UNSPSC Code:
23201100
Form:
lyophilized powder
Assay:
≥98% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in HEK 293 cells
biological source
human
Quality Level
recombinant
expressed in HEK 293 cells
assay
≥98% (SDS-PAGE)
form
lyophilized powder
potency
≥98% Heavy amino acids incorporation efficiency by MS
technique(s)
mass spectrometry (MS): suitable
suitability
suitable for mass spectrometry (internal calibrator)
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... CCL2(6347)
General description
CCL2, the most thoroughly characterized CC chemokine, is a monocyte-specific chemoattractant that was demonstrated to attract T lymphocytes and NK cells, but not neutrophils. Enhanced expression of CCL2 was demonstrated in a variety of pathologic conditions, associated with inflammation and mononuclear cell infiltration. Extensive experimental evidence suggests that CCL2 is highly expressed in atherosclerotic plaques. In a recent study, CCL2 was shown to have value as a biomarker for risk stratification in both the initial and the chronic phases after an acute coronary syndromes (ACS). In contrast to CRP, CCL2 levels may be an indicator of long-term cardiovascular risk rather than a marker of acute prognosis. In urine, CCL2 levels were directly associated to Systemic Lupus Erythematosus disease activity, making it a non-invasive biomarker (avoiding blood sampling or tissue biopsies).
Immunogen
QPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKTDYKDDDDKGHHHHHHHHGGQ
Biochem/physiol Actions
SILu™Lite CCL2 is a recombinant human protein expressed in human 293 cells. It is a homodimer consisting of 96 amino acids (including C-terminal polyhistidine and FLAG® tags), with a calculated molecular mass of 11 kDa. SILu Lite CCL2 is an analytical standard designed to be used as starting material for preparation of calibrators and controls in LC-MS applications.
Physical form
Lyophilized from a solution of phosphate buffered saline.
Legal Information
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
SILu is a trademark of Sigma-Aldrich Co. LLC
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Instructions
Xue Liu et al.
Genetics and molecular biology, 44(4), e20200463-e20200463 (2021-11-23)
Pain is a significant problem worldwide that affects the quality of life of patients. Dezocine is a non-addictive analgesic drug with kappa-opioid antagonist activity and has been successfully used to alleviate of postoperative pain. In addition, dezocine has an analgesic
Global Trade Item Number
| SKU | GTIN |
|---|---|
| MSST0036-50UG | 04061833255186 |