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Merck
CN

N0287

NNC 55-0396 hydrate

≥98% (HPLC)

Synonym(s):

(1S,2S)-2-(2-(N-[(3-Benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride hydrate, NNC55-0396

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About This Item

Empirical Formula (Hill Notation):
C30H40Cl2FN3O2 · xH2O
Molecular Weight:
564.56 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
24278523
UNSPSC Code:
12352200
MDL number:
MFCD12910446

Key Documents

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Product Name

NNC 55-0396 hydrate, ≥98% (HPLC)

InChI

1S/C30H38FN3O2.2ClH.H2O/c1-20(2)28-24-13-12-23(31)19-22(24)14-15-30(28,36-29(35)21-10-11-21)16-18-34(3)17-6-9-27-32-25-7-4-5-8-26(25)33-27;;;/h4-5,7-8,12-13,19-21,28H,6,9-11,14-18H2,1-3H3,(H,32,33);2*1H;1H2/t28-,30-;;;/m0.../s1

SMILES string

O.Cl.Cl.CC(C)[C@H]1c2ccc(F)cc2CC[C@@]1(CCN(C)CCCc3nc4ccccc4[nH]3)OC(=O)C5CC5

InChI key

ICVIUVXDXJUZRQ-SHQDEPIZSA-N

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H2O: >10 mg/mL

originator

Roche

storage temp.

2-8°C

Quality Level

200

Related Categories

Biochem/physiol Actions

NNC-55-0396 is a T-type calcium channel antagonists. It is the structural analog of mibefradil. NNC-55-0396 has the ability to block cell proliferation and stimulate cell apoptosis in leukemia cell lines.
Selective T-type calcium channel inhibitor

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000069382
0000063384
0000063383
0000051427
0000043706

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Luping Huang et al.
The Journal of pharmacology and experimental therapeutics, 309(1), 193-199 (2004-01-14)
Mibefradil is a Ca2+ channel antagonist that inhibits both T-type and high-voltage-activated Ca2+ channels. We previously showed that block of high-voltage-activated channels by mibefradil occurs through the production of an active metabolite by intracellular hydrolysis. In the present study, we
Xianjie Wen et al.
PloS one, 8(5), e62942-e62942 (2013-05-10)
There is concern regarding neurotoxicity induced by the use of local anesthetics. A previous study showed that an overload of intracellular calcium is involved in the neurotoxic effect of some anesthetics. T-type calcium channels, which lower the threshold of action
Yanjun Zhao et al.
Neuron, 96(2), 355-372 (2017-10-13)
Compelling evidence links amyloid beta (Aβ) peptide accumulation in the brains of Alzheimer's disease (AD) patients with the emergence of learning and memory deficits, yet a clear understanding of the events that drive this synaptic pathology are lacking. We present
Sergio A Machado et al.
Scientific reports, 9(1), 19546-19546 (2019-12-22)
Sperm storage in the female reproductive tract after mating and before ovulation is a reproductive strategy used by many species. When insemination and ovulation are poorly synchronized, the formation and maintenance of a functional sperm reservoir improves the possibility of
Jesús Espinal-Enríquez et al.
Scientific reports, 7(1), 4236-4236 (2017-06-28)
Spermatozoa sea urchin swimming behaviour is regulated by small peptides from the egg outer envelope. Speract, such a peptide, after binding to its receptor in Strongylocentrotus purpuratus sperm flagella, triggers a signaling pathway that culminates with a train of intracellular
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