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N0758

Naphthol AS-D chloroacetate

Name: Naphthol AS-D chloroacetate
Brand: SIGMA

esterase substrate, fluorogenic, ≥98% (TLC), powder

Synonym(s):

3-Hydroxy-2-naphthoic-o-toluidide chloroacetate

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₆ClNO₃

CAS Number:

35245-26-2

Molecular Weight:

353.80

NACRES:

NA.83

PubChem Substance ID:

24897441

UNSPSC Code:

12352204

EC Number:

252-463-5

MDL number:

MFCD00042714

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Product Name

Naphthol AS-D chloroacetate, esterase substrate

Quality Level

200

assay

≥98% (TLC)

form

powder

solubility

acetone: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

Cc1ccccc1NC(=O)c2cc3ccccc3cc2OC(=O)CCl

InChI

1S/C20H16ClNO3/c1-13-6-2-5-9-17(13)22-20(24)16-10-14-7-3-4-8-15(14)11-18(16)25-19(23)12-21/h2-11H,12H2,1H3,(H,22,24)

InChI key

FMVKYSCWHDVMGO-UHFFFAOYSA-N

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Proteins & Enzymes

Detection Substrates & Enzymes

General description

Substrate for histochemical localization of esterases

Application

Naphthol AS-D chloroacetate has been in a substrate solution for naphthol-AS-D-chloroacetate-esterase (CIAE) staining.

Naphthol AS-D chloroacetate has been used as a component of the substrate solution for naphthol-AS-D-chloroacetate-esterase (CIAE) staining to detect:

the paraffin-embedded kidney tissues
polymorphonuclear (PMN) cells
endometrial tissues
neutrophils from mice small intestine

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury

Maekawa H, et al.

Cell Reports, 29(5), 1261-1273 (2019)

Validation of a deep learning-based image analysis system to diagnose subclinical endometritis in dairy cows.

Hafez Sadeghi et al.

PloS one, 17(1), e0263409-e0263409 (2022-01-29)

The assessment of polymorphonuclear leukocyte (PMN) proportions (%) of endometrial samples is the hallmark for subclinical endometritis (SCE) diagnosis. Yet, a non-biased, automated diagnostic method for assessing PMN% in endometrial cytology slides has not been validated so far. We aimed

Muscarinic receptors control markers of inflammation in the small intestine of BALB/c mice.

Ivonne Maciel Arciniega-Martínez et al.

Journal of neuroimmunology, 362, 577764-577764 (2021-11-26)

Muscarinic-acetylcholine-receptors (mAChRs) modulate intestinal homeostasis, but their role in inflammation is unclear; thus, this issue was the focus of this study. BALB/c mice were treated for 7 days with muscarine (mAChR/agonist), atropine (mAChR/antagonist) or saline. Small-intestine samples were collected for histology

Complement depletion protects lupus-prone mice from ischemia-reperfusion-initiated organ injury.

Antonis Ioannou et al.

American journal of physiology. Gastrointestinal and liver physiology, 304(3), G283-G292 (2012-10-30)

Ischemia-reperfusion (IR) injury causes a vigorous immune response that is amplified by complement activation, leading to local and remote tissue damage. Using MRL/lpr mice, which are known to experience accelerated tissue damage after mesenteric IR injury, we sought to evaluate

Restoration of hepatic mast cells and expression of a different mast cell protease phenotype in regenerating rat liver after 70%-hepatectomy.

Martin Zweifel et al.

Immunology and cell biology, 83(6), 587-595 (2005-11-04)

Mast cells (MC) can undergo significant changes in number and phenotype; these alterations result in the differential expression of growth factors and cytokines. Kit ligand (KL; stem cell factor) is produced by mesenchymal cells, and in the liver by biliary

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Global Trade Item Number

SKU	GTIN
N0758-500MG	04061834093053
N0758-250MG	04061834093046
N0758-100MG	04061834093022
N0758-1G	04061834093039

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