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Merck
CN

N0915

NSC43067

≥98% (HPLC)

Synonym(s):

1-(5-Methyl-2-thienyl)-3-phenyl-2-Propen-1-one, 1-(5-Methyl-thiophen-2-yl)-3-phenyl-propenone, NSC 43067

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About This Item

Empirical Formula (Hill Notation):
C14H12OS
CAS Number:
26903-26-4
Molecular Weight:
228.31
NACRES:
NA.77
PubChem Substance ID:
329818472
UNSPSC Code:
12352202
MDL number:
MFCD00489751

Key Documents

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InChI key

AOUMOFQEBZGSPD-CMDGGOBGSA-N

SMILES string

Cc1ccc(s1)C(=O)\C=C\c2ccccc2

InChI

1S/C14H12OS/c1-11-7-10-14(16-11)13(15)9-8-12-5-3-2-4-6-12/h2-10H,1H3/b9-8+

assay

≥98% (HPLC)

form

powder

color

light yellow to light tan

solubility

DMSO: >20 mg/mL

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cyclin-dependent kinase (Cdk) inhibitor which binds to a novel conserved site on Cdk, presumably the p27 binding pocket.
NSC43067 is a Cyclin-dependent kinase (Cdk) inhibitor which binds to a novel conserved site on Cdk, presumably the p27 binding pocket. The binding apparently directly induces Cdk1, Cdk2, and Cdk4 protein aggregation. Cdks 1, 2, 4, and 6 are the key Cdks that regulate the cell cycle, and are a target for a cancer treatment. NSC43067 arrests the cell cycle at the G0/G1 phase at lower concentrations and at the G2/M cell cycle phase at higher concentrations. The action appears to be reversible.

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H413

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
030M4624

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Diksha Kaushik et al.
International journal of pharmaceutics, 386(1-2), 42-51 (2009-11-11)
The enhancement/retardation of percutaneous permeation of diethyl-m-toluamide (DEET) in the presence of five percutaneous penetration modifiers (laurocapram, 3-dodecanoyloxazolidin-2-one (N-0915), S,S-dimethyl-N-(4-bromobenzoyl) iminosulfurane (DMBIS), S,S-dimethyl-N-(2-methoxycarbonylbenzenesulfonyl) iminosulfurane (DMMCBI) and tert-butyl 1-dodecyl-2-oxoazepan-3-yl-carbamate (TBDOC)) was investigated. These permeation modifiers were formulated in either water, propylene

Articles

Cyclin-dependent Kinases (CDKs)

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