N0915
NSC43067
≥98% (HPLC)
Synonym(s):
1-(5-Methyl-2-thienyl)-3-phenyl-2-Propen-1-one, 1-(5-Methyl-thiophen-2-yl)-3-phenyl-propenone, NSC 43067
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About This Item
Empirical Formula (Hill Notation):
C14H12OS
CAS Number:
Molecular Weight:
228.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
light yellow to light tan
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
SMILES string
Cc1ccc(s1)C(=O)\C=C\c2ccccc2
InChI
1S/C14H12OS/c1-11-7-10-14(16-11)13(15)9-8-12-5-3-2-4-6-12/h2-10H,1H3/b9-8+
InChI key
AOUMOFQEBZGSPD-CMDGGOBGSA-N
Biochem/physiol Actions
Cyclin-dependent kinase (Cdk) inhibitor which binds to a novel conserved site on Cdk, presumably the p27 binding pocket.
NSC43067 is a Cyclin-dependent kinase (Cdk) inhibitor which binds to a novel conserved site on Cdk, presumably the p27 binding pocket. The binding apparently directly induces Cdk1, Cdk2, and Cdk4 protein aggregation. Cdks 1, 2, 4, and 6 are the key Cdks that regulate the cell cycle, and are a target for a cancer treatment. NSC43067 arrests the cell cycle at the G0/G1 phase at lower concentrations and at the G2/M cell cycle phase at higher concentrations. The action appears to be reversible.
Features and Benefits
This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 4
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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