N1408
Nerve Growth Factor β Human
>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
Synonym(s):
HSAN5, NGF-β human, NGFB, hNGFβ
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About This Item
Biological source:
human
Recombinant:
expressed in NSO cells
Assay:
>97% (SDS-PAGE)
Form:
lyophilized powder
Impurities:
<1 EU/μg
Product Name
NGF-β human, from human, recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
biological source
human
Quality Segment
recombinant
expressed in NSO cells
assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
0.15-3.0 ng/mL ED50/EC50
quality
endotoxin tested
packaging
pkg of 5X0.1 mg, pkg of 0.1 mg
technique(s)
cell culture | mammalian: suitable
impurities
<1 EU/μg
solubility
water: soluble 0.1 g/L at 20 °C
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... NGF(4803)
General description
The nerve growth factor β (NGFB) gene is mapped to human chromosome 1p13.2.
Application
NGF-β human has been used:
- in protein pin arrays
- to induce U87-MG (glioblastoma cell line) cell proliferation
- in drug release kinetics
Biochem/physiol Actions
Nerve growth factor β (NGFB) acts as a key mediator in neuronal and non-neuronal development, differentiation, and survival. Polymorphism of NGFB gene leads to hereditary sensory and autonomic neuropathies. Charcot arthropathy and thermal insensitivity are few of the related symptoms. NGFβ is known to promote cancer cell proliferation and metastasis, also mediates angiogenesis. It facilitates the development of various cancer including, oral, breast, lungs, pancreatic and prostate cancers. Elevated expression of NGFβ contributes to progression of human cholangiocarcinoma. In animal models, NGFβ is observed to prevent cholinergic neuron loss and enhances memory. NGF-β promotes the survival and cholinergic phenotype of basal forebrain cholinergic neurons and stimulates neurite outgrowth of embryonic trigeminal motor neurons in vitro.
Physical form
Lyophilized from 0.2% acetic acid containing 5 mg bovine serum albumin.
Analysis Note
The biological activity is measured in a cell proliferation assay using a factor-dependent human erythroleukemic cell line, TF-1.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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