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About This Item

Empirical Formula (Hill Notation):
C17H21NO2 · HCl
CAS Number:
Molecular Weight:
307.82
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Quality Level

Assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white to beige

solubility

H2O: 20 mg/mL
ethanol: 50 mg/mL

SMILES string

Cl[H].CNCCC(Oc1ccccc1OC)c2ccccc2

InChI

1S/C17H21NO2.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2;/h3-11,15,18H,12-13H2,1-2H3;1H

InChI key

LCEURBZEQJZUPV-UHFFFAOYSA-N

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Application

Nisoxetine has been used as a norepinephrine transport (NET) blocker in autoradiography studies. It has also been used as a NET blocker to study its effects on perivascular adipose tissue.

Biochem/physiol Actions

Nisoxetine is a selective and potent noradrenaline reuptake inhibitor. It has a high affinity towards the noradrenaline transporter. Nisoxetine possesses antidepressant activity.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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