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N1530

Nomifensine maleate salt

Name: Nomifensine maleate salt
Brand: SIGMA

dopamine uptake inhibitor , powder

Synonym(s):

1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine maleate salt

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₈N₂ · C₄H₄O₄

CAS Number:

32795-47-4

Molecular Weight:

354.40

NACRES:

NA.77

PubChem Substance ID:

24277920

UNSPSC Code:

12352200

EC Number:

251-223-7

MDL number:

MFCD00069320

Form:

powder

Quality level:

200

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Product Name

Nomifensine maleate salt,

form

powder

Quality Level

200

SMILES string

[H]\C(=C(/[H])C(O)=O)C(O)=O.CN1CC(c2ccccc2)c3cccc(N)c3C1

InChI

1S/C16H18N2.C4H4O4/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18;5-3(6)1-2-4(7)8/h2-9,14H,10-11,17H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

GEOCVSMCLVIOEV-BTJKTKAUSA-N

Gene Information

human ... DBH(1621), SLC6A2(6530), SLC6A3(6531), SLC6A4(6532)

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

Nomifensine maleate salt has been used to study the β-CFT (cocaine analogue) binding using human embryonic kidney 293T cells.

Biochem/physiol Actions

Nomifensine maleate is a selective dopamine uptake inhibitor interacting with the dopamine transporter, at a site different from that of cocaine; antidepressant. Nomifensine serves as an antidepressant and is known to cause frequent hemolytic anemia. The aniline group in this compound results in blood and liver toxicities.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000530592

0000515471

0000404435

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Tracking tonic dopamine levels in vivo using multiple cyclic square wave voltammetry.

Yoonbae Oh et al.

Biosensors & bioelectronics, 121, 174-182 (2018-09-16)

For over two decades, fast-scan cyclic voltammetry (FSCV) has served as a reliable analytical method for monitoring dopamine release in near real-time in vivo. However, contemporary FSCV techniques have been limited to measure only rapid (on the order of seconds

Kinetic evaluation of the commonality between the site(s) of action of cocaine and some other structurally similar and dissimilar inhibitors of the striatal transporter for dopamine.

S M Meiergerd et al.

Journal of neurochemistry, 63(5), 1683-1692 (1994-11-01)

The inhibition by cocaine of the apparent initial rate of the transport of striatal dopamine was compared with inhibitions produced by cocaethylene, benztropine, GBR-12909, mazindol, and nomifensine. Rotating disk electrode voltammetry was used to measure the kinetically resolved, inwardly directed

Designing a norepinephrine optical tracer for imaging individual noradrenergic synapses and their activity in vivo.

Matthew Dunn et al.

Nature communications, 9(1), 2838-2838 (2018-07-22)

Norepinephrine is a monoamine neurotransmitter with a wide repertoire of physiological roles in the peripheral and central nervous systems. There are, however, no experimental means to study functional properties of individual noradrenergic synapses in the brain. Development of new approaches

Metabolism of nomifensine to a dihydroisoquinolinium ion metabolite by human myeloperoxidase, hemoglobin, monoamine oxidase-A, and cytochrome P450 enzymes

Obach RS and Dalvie DK

Drug Metabolism and Disposition (2006)

A rotarod test for evaluation of motor skill learning.

Hiromi Shiotsuki et al.

Journal of neuroscience methods, 189(2), 180-185 (2010-04-03)

The rotarod test is widely used to evaluate the motor coordination of rodents, and is especially sensitive in detecting cerebellar dysfunction. However, mice with striatal dopamine depletion show only mild or no motor deficit on the typical accelerating rotarod. This

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Global Trade Item Number

SKU	GTIN
N1530-100MG	04061834109518

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