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N1537

NU7026

≥98% (HPLC), solid

Synonym(s):

2-(Morpholin-4-yl)-benzo[h]chromen-4-one

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About This Item

Empirical Formula (Hill Notation):
C17H15NO3
CAS Number:
154447-35-5
Molecular Weight:
281.31
NACRES:
NA.77
PubChem Substance ID:
329818582
UNSPSC Code:
12352200
MDL number:
MFCD06798345
Assay:
≥98% (HPLC)
Form:
solid
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Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

tan

solubility

DMSO: soluble 3 mg/mL at 60 °C, H2O: insoluble

shipped in

wet ice

storage temp.

2-8°C

SMILES string

O=C1C=C(Oc2c1ccc3ccccc23)N4CCOCC4

InChI

1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2

InChI key

KKTZALUTXUZPSN-UHFFFAOYSA-N

Application

NU7026 has been used:
  • as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell
  • in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)
  • to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells

Potent, ATP-competitive. IC50 = 0.23 μM. Selectivity over other PI3K-related kinases (IC50 = 13 μM for PI3K and >100 μM for ATM and ATR).

Biochem/physiol Actions

Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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