N170
NS 1619
powder
Synonym(s):
1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
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About This Item
Empirical Formula (Hill Notation):
C15H8F6N2O2
CAS Number:
Molecular Weight:
362.23
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
form
powder
Quality Level
color
white
solubility
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47 mg/mL, ethanol: 26.6 mg/mL, 0.1 M NaOH: 5.2 mg/mL, DMSO: 5.3 mg/mL, H2O: insoluble
SMILES string
Oc1ccc(cc1N2C(=O)Nc3cc(ccc23)C(F)(F)F)C(F)(F)F
InChI
1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
InChI key
YLFMCMWKHSDUCT-UHFFFAOYSA-N
Gene Information
mouse ... Kcnma1(16531)
rat ... Kcnma1(83731)
Application
NS 1619 has been used as calcium-activated potassium channels (BK)-activator: to study its vaso-relaxing effects on the thoracic aortic rings from mice, to evaluate its effects on the sarco-/endoplasmic reticulum Ca2+-ATPase (SERCA) activity from skeletal muscles, to determine its effects on the expression of caveolin-1 protein in mice brain tumor microvascular endothelial cells
Biochem/physiol Actions
NS 1619 is a selective large conductance Ca2+-activated K+-channel activator. The compound is known for its vasodilating and anti-proliferative properties. It is studied that NS 1619 can protect cardiac muscle against ischemia and reperfusion injury.
NS-1619 can promote the formation of mitochondrial reactive oxygen species (ROS) in cardiac myocytes. It enhances the formation of ROS in cultured brain slices. NS-1619 has the ability to enhance HO-1 activity in wild-type (WT) animals.
Disclaimer
Photosensitive
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Rui-Ping Cai et al.
Journal of the neurological sciences, 369, 109-118 (2016-09-23)
NS1619, a calcium-activated potassium channel (Kca channel) activator, can selectively and time-dependently accelerate the formation of transport vesicles in both the brain tumor capillary endothelium and tumor cells within 15min of treatment and then increase the permeability of the blood-brain
Rupal P Soder et al.
European journal of pharmacology, 670(1), 252-259 (2011-09-15)
Large conductance voltage- and Ca(2+)-activated K(+) (BK) channels are important in regulating detrusor smooth muscle (DSM) function. Here, we examined systematically how the BK channel pharmacological activation modulates DSM contractility. NS1619, a potent BK channel activator, was utilized as a
Antoni Wrzosek
Cell calcium, 56(1), 14-24 (2014-05-13)
NS1619 (1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazole-2-one) is widely used as a large-conductance Ca(2+)-activated K(+) (BKCa) channel opener. It was previously reported that activation of BKCa channels by NS1619 could protect the cardiac muscle against ischaemia and reperfusion injury. This study reports the effects of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| N170-25MG | 04061834109716 |
| N170-5MG | 04061833621578 |