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N194

NS-398

Name: NS-398
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₈N₂O₅S

CAS Number:

123653-11-2

Molecular Weight:

314.36

NACRES:

NA.77

PubChem Substance ID:

24897540

UNSPSC Code:

12352200

MDL number:

MFCD00882995

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Quality Level

100

assay

≥98% (HPLC)

form

solid

color

off-white

mp

127-128 °C

solubility

DMSO: >5 mg/mL, H₂O: insoluble

SMILES string

CS(=O)(=O)Nc1ccc(cc1OC2CCCCC2)[N+]([O-])=O

InChI

1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3

InChI key

KTDZCOWXCWUPEO-UHFFFAOYSA-N

Gene Information

human ... ALOX5(240), CYP19A1(1588), PTGS1(5742), PTGS2(5743)
mouse ... Ptgs2(19225)

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Related Categories

Bioactive Small Molecule Inhibitors

Application

NS-398 has been used as a cyclooxygenase-2 (COX2) inhibitor to study its effects on:

the cardiac rate in zebrafish embryos
apoptosis and hypoxia/reoxygenation in rat cardiomyocytes
the lipopolysaccharide (LPS) induced anorexia in rats

Biochem/physiol Actions

NS-398 belongs to the non-steroidal anti-inflammatory drug (NSAID) family. It exhibits anti-inflammatory, analgesic, and anti-pyretic properties.

Selective cyclooxygenase-2 (COX-2) inhibitor.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000143800

091M4603V

0000143799

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Gas6 Prevents Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells via Production of PGE2, PGD2 and Their Receptors.

Jihye Jung et al.

Cells, 8(7) (2019-06-30)

The epithelial-mesenchymal transition (EMT) is important in organ fibrosis. We hypothesized that growth arrest-specific protein 6 (Gas6) and its underlying mechanisms play roles in the prevention of EMT in alveolar epithelial cells (ECs). In this study, to determine whether Gas6

Involvement of the P2X7 purinergic receptor and c-Jun N-terminal and extracellular signal-regulated kinases in cyclooxygenase-2 and prostaglandin E2 induction by LL-37.

Pareena Chotjumlong et al.

Journal of innate immunity, 5(1), 72-83 (2012-10-26)

Periodontal disease is caused by microorganisms and host-derived inflammation involving increased cyclooxygenase-2 (COX-2) expression and prostaglandin E(2) (PGE(2)) production. We previously demonstrated that human β-defensin-3 induces COX-2 and PGE(2) in human gingival fibroblasts (HGFs). We, therefore, aimed to examine the

PPARγ is critical for Mycobacterium tuberculosis induction of Mcl-1 and limitation of human macrophage apoptosis.

Eusondia Arnett et al.

PLoS pathogens, 14(6), e1007100-e1007100 (2018-06-22)

Peroxisome proliferator-activated receptor (PPAR)γ is a global transcriptional regulator associated with anti-inflammatory actions. It is highly expressed in alveolar macrophages (AMs), which are unable to clear the intracellular pathogen Mycobacterium tuberculosis (M.tb). Although M.tb infection induces PPARγ in human macrophages

Ethanol Extract of Potentilla supina Linne Suppresses LPS-induced Inflammatory Responses through NF-κB and AP-1 Inactivation in Macrophages and in Endotoxic mice.

Hae-Jun Lee et al.

Phytotherapy research : PTR, 31(3), 475-487 (2017-01-28)

In this study, we investigated the antiinflammatory effects of ethanol extracts of Potentilla. supina Linne (EPS) in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages and septic mice. EPS suppressed LPS-induced nitric oxide, prostaglandin E

TGF-β1 inhibits human trophoblast cell invasion by upregulating cyclooxygenase-2.

Yuyin Yi et al.

Placenta, 68, 44-51 (2018-07-30)

Enhanced expression and activity of cyclooxygenase-2 (COX-2) has been reported in trophoblasts from women with preeclampsia compared with healthy pregnant women. Prostaglandin E2, the production of which is initiated by COX-2, and transforming growth factor-β1 (TGF-β1) have been shown to

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Global Trade Item Number

SKU	GTIN
N194-25MG	04061832785707
N194-5MG	04061834109976

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