N194
NS-398
≥98% (HPLC), solid
Synonym(s):
N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide
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About This Item
Empirical Formula (Hill Notation):
C13H18N2O5S
CAS Number:
Molecular Weight:
314.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality Segment
assay
≥98% (HPLC)
form
solid
color
off-white
mp
127-128 °C
solubility
DMSO: >5 mg/mL, H2O: insoluble
SMILES string
CS(=O)(=O)Nc1ccc(cc1OC2CCCCC2)[N+]([O-])=O
InChI
1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3
InChI key
KTDZCOWXCWUPEO-UHFFFAOYSA-N
Gene Information
human ... ALOX5(240), CYP19A1(1588), PTGS1(5742), PTGS2(5743)
mouse ... Ptgs2(19225)
Application
NS-398 has been used as a cyclooxygenase-2 (COX2) inhibitor to study its effects on:
- the cardiac rate in zebrafish embryos
- apoptosis and hypoxia/reoxygenation in rat cardiomyocytes
- the lipopolysaccharide (LPS) induced anorexia in rats
Biochem/physiol Actions
NS-398 belongs to the non-steroidal anti-inflammatory drug (NSAID) family. It exhibits anti-inflammatory, analgesic, and anti-pyretic properties.
Selective cyclooxygenase-2 (COX-2) inhibitor.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| N194-25MG | 04061832785707 |
| N194-5MG | 04061834109976 |