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Merck
CN

N2288

Nefiracetam

solid

Synonym(s):

(2-(2-Oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide), DM-9384

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About This Item

Empirical Formula (Hill Notation):
C14H18N2O2
CAS Number:
77191-36-7
Molecular Weight:
246.30
NACRES:
NA.77
PubChem Substance ID:
329818410
UNSPSC Code:
12352200
MDL number:
MFCD00209882
Form:
solid
Quality level:
100

Key Documents

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Product Name

Nefiracetam, solid

InChI

1S/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/h3,5-6H,4,7-9H2,1-2H3,(H,15,17)

SMILES string

Cc1cccc(C)c1NC(=O)CN2CCCC2=O

InChI key

NGHTXZCKLWZPGK-UHFFFAOYSA-N

form

solid

drug control

Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet

color

white to off-white

solubility

DMSO: >5 mg/mL

Quality Level

100

Biochem/physiol Actions

Nefiracetam (NEF) is a pyrrolidonetype nootropic agent with various pharmacologic as well as cognition enhancing effects. In amygdala-kindled seizures, nefiracetam inhibits both electroencephalographic and behavioral seizures. NEF has a distinct anticonvulsant spectrum.
Novel pyrrolidonetype nootropic (condition enhancing) agent with anticonvulsant spectrum.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000463169
120M4713V
0000463169
120M4713V
110M4709V

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Shigeki Moriguchi
Journal of pharmacological sciences, 117(1), 6-11 (2011-08-09)
In the brain of Alzheimer's disease patients, down-regulation of both cholinergic and glutamatergic systems have been found and is thought to play an important role in impairment of cognition, learning, and memory. Nefiracetam is a pyrrolidine-related nootropic drug exhibiting various
[Evaluation methods for the discriminative stimulus and possible mechanisms of discriminative stimulus effects of methamphetamine in the rat].
Hiroyuki Mizoguchi et al.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 126(1), 17-23 (2005-09-06)
Robert G Robinson et al.
The Journal of neuropsychiatry and clinical neurosciences, 21(2), 144-151 (2009-07-23)
Nefiracetam is a novel pyrrolidone-type nootropic compound shown in preliminary trials to increase blood flow and improve patient outlook and energy following stroke. Of 137 stroke patients with major depression, 70 also met published diagnostic criteria for apathy (51.1%) and
Ricardo E Jorge et al.
Canadian journal of psychiatry. Revue canadienne de psychiatrie, 55(6), 350-354 (2010-06-15)
We will review the available evidence on the frequency, clinical correlates, mechanism, and treatment of apathy following stroke. We have explored relevant databases (that is, PubMed, MEDLINE, and PsycINFO) using the following key words and their combinations: apathy, motivation, abulia
Yoshimi Tsuchiya et al.
Toxicologic pathology, 33(5), 561-569 (2005-08-18)
To ascertain the early pathophysiological features in canine renal papillary necrosis (RPN) caused by the neurotransmission enhancer nefiracetam, male beagle dogs were orally administered nefiracetam at 300 mg/kg/day for 4 to 7 weeks in comparison with ibuprofen, a non-steroidal anti-inflammatory
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