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Merck
CN

N3040

Necrostatin-7

≥98% (HPLC), powder

Synonym(s):

5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone, Nec-7

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About This Item

Empirical Formula (Hill Notation):
C16H10FN5OS2
CAS Number:
351062-08-3
Molecular Weight:
371.41
UNSPSC Code:
12352202
PubChem Substance ID:
329818601
MDL number:
MFCD02334728

Key Documents

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InChI

1S/C16H10FN5OS2/c17-11-3-1-9(2-4-11)13-10(8-20-21-13)7-12-14(23)22(15(18)25-12)16-19-5-6-24-16/h1-8,18H,(H,20,21)

SMILES string

Fc1ccc(cc1)-c2n[nH]cc2C=C3SC(=N)N(C3=O)c4nccs4

InChI key

SMJGLNVGTJLIRV-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

yellow to tan

solubility

DMSO: >10 mg/mL (with warming)

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Necrostatin-7 (Nec-7) is a potent inhibitor of necroptosis, a regulated caspase-independent necrotic cell death pathway, distinct from apoptosis. Nec-7 has a different profile from the other necrostatins as it does not inhibit RIP1 kinase, suggesting the possibility that it may target an additional as yet unknown regulatory molecule in the pathway.
Necrostatin-7 is a potent inhibitor of necroptosis.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
021M4617V

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