N3040
Necrostatin-7
≥98% (HPLC), powder
别名:
5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone, Nec-7
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
yellow to tan
溶解性
DMSO: >10 mg/mL (with warming)
储存温度
2-8°C
SMILES字符串
Fc1ccc(cc1)-c2n[nH]cc2C=C3SC(=N)N(C3=O)c4nccs4
InChI
1S/C16H10FN5OS2/c17-11-3-1-9(2-4-11)13-10(8-20-21-13)7-12-14(23)22(15(18)25-12)16-19-5-6-24-16/h1-8,18H,(H,20,21)
InChI key
SMJGLNVGTJLIRV-UHFFFAOYSA-N
相关类别
生化/生理作用
Necrostatin-7 (Nec-7) is a potent inhibitor of necroptosis, a regulated caspase-independent necrotic cell death pathway, distinct from apoptosis. Nec-7 has a different profile from the other necrostatins as it does not inhibit RIP1 kinase, suggesting the possibility that it may target an additional as yet unknown regulatory molecule in the pathway.
Necrostatin-7 is a potent inhibitor of necroptosis.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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