N3040
Necrostatin-7
≥98% (HPLC), powder
别名:
5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone, Nec-7
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选择尺寸
关于此项目
经验公式（希尔记法）:
C16H10FN5OS2
化学文摘社编号:
分子量:
371.41
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
InChI
1S/C16H10FN5OS2/c17-11-3-1-9(2-4-11)13-10(8-20-21-13)7-12-14(23)22(15(18)25-12)16-19-5-6-24-16/h1-8,18H,(H,20,21)
SMILES string
Fc1ccc(cc1)-c2n[nH]cc2C=C3SC(=N)N(C3=O)c4nccs4
InChI key
SMJGLNVGTJLIRV-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
yellow to tan
solubility
DMSO: >10 mg/mL (with warming)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Necrostatin-7 (Nec-7) is a potent inhibitor of necroptosis, a regulated caspase-independent necrotic cell death pathway, distinct from apoptosis. Nec-7 has a different profile from the other necrostatins as it does not inhibit RIP1 kinase, suggesting the possibility that it may target an additional as yet unknown regulatory molecule in the pathway.
Necrostatin-7 is a potent inhibitor of necroptosis.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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