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N3376

Nicotinamide

Name: Nicotinamide
Brand: SIGMA

≥98% (HPLC), powder, PARP inhibitor

Synonym(s):

Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B₃, Vitamin PP

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About This Item

Empirical Formula (Hill Notation):

C₆H₆N₂O

CAS Number:

98-92-0

Molecular Weight:

122.12

NACRES:

NA.77

PubChem Substance ID:

24897638

UNSPSC Code:

12352200

EC Number:

202-713-4

MDL number:

MFCD00006395

Beilstein/REAXYS Number:

383619

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

200

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Product Name

Nicotinamide, ≥98% (HPLC), powder

Quality Level

200

assay

≥98% (HPLC)

form

powder

color

white

mp

128-131 °C (lit.)

application(s)

cell analysis

SMILES string

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChI key

DFPAKSUCGFBDDF-UHFFFAOYSA-N

Gene Information

human ... PARP1(142), SIRT2(22933)

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Related Categories

Bioactive Small Molecules

Biochemicals

Cell Culture Supplements & Reagents

Vitamins

Application

Used as a cofactor for certain enzymes

Biochem/physiol Actions

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Preparation Note

This product can be stored tightly closed in room temperature and in dry conditions.

pictograms

GHS07

signalword

Warning

hcodes

H319

pcodes

P264 - P280 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

flash_point_f

302.0 °F - closed cup

flash_point_c

150 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D.

Christian W Johnson et al.

Cell reports, 28(6), 1538-1550 (2019-08-08)

Ras GTPases are mutated at codons 12, 13, and 61, with different frequencies in KRas, HRas, and NRas and in a cancer-specific manner. The G13D mutant appears in 25% of KRas-driven colorectal cancers, while observed only rarely in HRas or

Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: overall survival analysis and updated results from a randomised phase 3 trial.

Robert J Motzer et al.

The Lancet. Oncology, 14(6), 552-562 (2013-04-20)

In a phase 3 trial comparing the efficacy and safety of axitinib versus sorafenib as second-line treatment for metastatic renal cell carcinoma, patients given axitinib had a longer progression-free survival (PFS). Here, we report overall survival and updated efficacy, quality

Hepatocellular carcinoma: clinical frontiers and perspectives.

Jordi Bruix et al.

Gut, 63(5), 844-855 (2014-02-18)

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death and is currently the main event leading to death in patients with cirrhosis. Evolving information suggests that the metabolic syndrome with non-alcoholic liver disease may be an important

Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2.

Salvatore Simmini et al.

Nature communications, 5, 5728-5728 (2014-12-17)

The endodermal lining of the adult gastro-intestinal tract harbours stem cells that are responsible for the day-to-day regeneration of the epithelium. Stem cells residing in the pyloric glands of the stomach and in the small intestinal crypts differ in their

SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer.

Xiao-bin Lv et al.

Scientific reports, 5, 17940-17940 (2015-12-15)

SUN2, a key component of LINC (linker of nucleoskeleton and cytoskeleton) complex located at the inner nuclear membrane, plays unknown role in lung cancer. We found that SUN2 expression was decreased in lung cancer tissue compared with paired normal tissues

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Global Trade Item Number

SKU	GTIN
N3376-500G	04061834115984
N3376-100G	04061834115977
N3376-1KG	04061826236772

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