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N3501

β-Nicotinamide mononucleotide

Name: β-Nicotinamide mononucleotide
Brand: SIGMA

≥95% (HPLC)

Synonym(s):

β-NMN, β-Nicotinamide ribose monophosphate, NMN, Nicotinamide ribotide, Nicotinamide-1-ium-1-β-D-ribofuranoside 5′-phosphate

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₅N₂O₈P

CAS Number:

1094-61-7

Molecular Weight:

334.22

UNSPSC Code:

41106305

NACRES:

NA.51

PubChem Substance ID:

24897645

EC Number:

214-136-5

Beilstein/REAXYS Number:

3570187

MDL number:

MFCD00038748

Form:

powder

Assay:

≥95% (HPLC), ≥95% (spectrophotometric assay)

Solubility:

H₂O: soluble-50 mg/mL to clear, colorless to faintly yellow

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Quality Level

200

assay

≥95% (HPLC), ≥95% (spectrophotometric assay)

form

powder

solubility

H₂O: soluble-50 mg/mL to clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

C[C@H]1[C@@H](C)[C@@H](O[C@@H]1COP(O)([O-])=O)[n+]2cccc(c2)C(N)=O

InChI

1S/C13H19N2O6P/c1-8-9(2)13(21-11(8)7-20-22(17,18)19)15-5-3-4-10(6-15)12(14)16/h3-6,8-9,11,13H,7H2,1-2H3,(H3-,14,16,17,18,19)/t8-,9+,11+,13+/m0/s1

InChI key

YYNOOWWEYJELSF-SEMCEJNYSA-N

General description

β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the nicotinamide phosphoribosyltransferase (NAMPT)-catalyzed biosynthesis of nicotinamide adenine dinucleotide (NAD+). NAMPT mediates the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to produce β-NMN. β-NMN adenyltransferase subsequently converts β-NMN to NAD+.

Application

β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.

Other Notes

Note: This is the common form of NMN. Do not confuse it with α-NMN.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn

João Meireles Ribeiro et al.

Scientific reports, 8(1), 1036-1036 (2018-01-20)

Cyclic ADP-ribose (cADPR) is a messenger for Ca

RNA aptamers that bind flavin and nicotinamide redox cofactors.

C T Lauhon et al.

Journal of the American Chemical Society, 117(4), 1246-1257 (1995-02-01)

RNA molecules that specifically bind riboflavin (Rb) and beta-nicotinamide mononucleotide (NMN) have been isolated by in vitro selection. A simple structural motif containing intramolecular G-quartets was found to bind tightly to oxidized riboflavin (Kd = 1-5 micromolar). DNA versions of

An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers.

Sophia E Airhart et al.

PloS one, 12(12), e0186459-e0186459 (2017-12-07)

The co-primary objectives of this study were to determine the human pharmacokinetics (PK) of oral NR and the effect of NR on whole blood nicotinamide adenine dinucleotide (NAD+) levels. Though mitochondrial dysfunction plays a critical role in the development and

Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes.

Kazuhiro Hasegawa et al.

Nature medicine, 19(11), 1496-1504 (2013-10-22)

Sirtuin 1 (Sirt1), a NAD(+)-regulated deacetylase with numerous known positive effects on cellular and whole-body metabolism, is expressed in the renal cortex and medulla. It is known to have protective effects against age-related disease, including diabetes. Here we investigated the

Investigation of non-linear Mate1-mediated efflux of trimethoprim in the mouse kidney as the mechanism underlying drug-drug interactions between trimethoprim and organic cations in the kidney.

Tomoko Kito et al.

Drug metabolism and pharmacokinetics, 34(1), 87-94 (2018-12-12)

The purpose of this study was to elucidate the involvement of Mate1 in the tubular secretion of trimethoprim and saturation of Mate1-mediated efflux to address the mechanisms underlying the pharmacokinetic drug interactions with trimethoprim. Trimethoprim is a more potent inhibitor

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Global Trade Item Number

SKU	GTIN
N3501-500MG	04061834116110
N3501-100MG	04061834116080
N3501-250MG	04061834116097
N3501-25MG	04061834116103

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