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N3905

Nicarbazin

Name: Nicarbazin
Brand: SIGMA

Synonym(s):

N,N′-bis(4-Nitrophenyl)urea compound with 4,6-dimethyl-2-pyrimidinone

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₀N₄O₅ · C₆H₈N₂O

CAS Number:

330-95-0

Molecular Weight:

426.38

NACRES:

NA.85

PubChem Substance ID:

329818641

UNSPSC Code:

51102829

EC Number:

206-359-1

MDL number:

MFCD00867204

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form

powder

Quality Level

100

antibiotic activity spectrum

parasites

mode of action

cell membrane | interferes

SMILES string

Cc1cc(C)nc(O)n1.[O-][N+](=O)c2ccc(NC(=O)Nc3ccc(cc3)[N+]([O-])=O)cc2

InChI

1S/C13H10N4O5.C6H8N2O/c18-13(14-9-1-5-11(6-2-9)16(19)20)15-10-3-7-12(8-4-10)17(21)22;1-4-3-5(2)8-6(9)7-4/h1-8H,(H2,14,15,18);3H,1-2H3,(H,7,8,9)

InChI key

UKHWDRMMMYWSFL-UHFFFAOYSA-N

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Application

Nicarbazin is a coccidiostat (antiprotozoal agent) in the poultry industry and is a contraceptive for resident Canada geese and waterfowl. It is used to study avian reproduction and is used to interfere with the formation of the vitelline (yolk) membrane in bird eggs. It has been used to study how delivery method can effect plasma levels of 4,4′-dinitrocarbanilide (DNC), which is the active anticoccidial component of Nicarbazin.

Biochem/physiol Actions

Nicarbazin affects avian reproduction by reducing egg production, egg weight, and egg hatchability. The mechanism of action of Nicarbazin is unknown.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Coccidiosis control by administering toltrazuril in the drinking water for a 2-day period.

G F Mathis et al.

Veterinary parasitology, 121(1-2), 1-9 (2004-04-28)

A 56-day floor pen study was conducted to determine the appropriate time to administer toltrazuril (Baycox) (TOL) for control of coccidiosis in broiler chickens. Litter was seeded with field strains of Eimeria acervulina, Eimeria maxima and Eimeria tenella. On Days

Survey of the anticoccidial feed additive nicarbazin (as dinitrocarbanilide residues) in poultry and eggs.

Martin Danaher et al.

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 25(1), 32-40 (2007-10-25)

A survey was carried out on the occurrence of dinitrocarbanilide (DNC), the marker residue for nicarbazin, in poultry produced in Ireland during 2002-2004. Liver (n = 736) and breast muscle samples (n = 342) were tested. DNC residues were found

Application of total error approach to assess the performance of a biological method (ELISA) to detect nicarbazin residues in eggs.

V Gaudin et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(23), 2358-2362 (2009-04-07)

Nicarbazin, a coccidiostat, is used as a feed additive in poultry but not in laying hens. Feed contamination may however occur resulting in residues being present in eggs. As a Maximum Residue Limit (MRL) does not exist for nicarbazin residues

Screening for the coccidiostats halofuginone and nicarbazin in egg and chicken muscle: development of an ELISA.

A-C Huet et al.

Food additives and contaminants, 22(2), 128-134 (2005-04-13)

Nicarbazin and halofuginone have been widely used as coccidiostats for the prevention and treatment of coccidiosis in poultry. It has been shown that accidental cross-contamination of feed can lead to residues of these compounds in eggs and/or muscle. This paper

Investigation of the causes for the occurrence of residues of the anticoccidial feed additive nicarbazin in commercial poultry.

M O'Keeffe et al.

Food additives and contaminants, 24(9), 923-934 (2007-08-11)

Investigations were undertaken to identify causes for the occurrence of high levels of the zootechnical feed additive nicarbazin in broiler liver at slaughter. The first investigation on 32 commercial broiler flocks involved sampling and analysis for nicarbazin (as dinitrocarbanilide, DNC)

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Global Trade Item Number

SKU	GTIN
N3905-100G	04061834116370

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