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Merck
CN

N3911

NBI 27914

≥98% (HPLC)

Synonym(s):

5-Chloro-4-(N-(cyclopropyl)methyl-N-propylamino)-2-methyl-6-(2,4,6-trichlorophenyl)aminopyridine

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About This Item

Empirical Formula (Hill Notation):
C18H20Cl4N4
CAS Number:
184241-44-9
Molecular Weight:
434.19
NACRES:
NA.77
PubChem Substance ID:
24278425
UNSPSC Code:
12352200
MDL number:
MFCD05662281

Key Documents

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Product Name

NBI 27914, ≥98% (HPLC)

InChI

1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)

SMILES string

CCCN(CC1CC1)c2nc(C)nc(Nc3c(Cl)cc(Cl)cc3Cl)c2Cl

InChI key

KNADXBVKFAUMCR-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >20 mg/mL at 60 °C
H2O: insoluble

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... CRHR1(1394)

Application

NBI 27914 has been used as acorticotropin-releasing hormone receptor (CRHR1) antagonist:
  • to study its effects on steroidogenic gene expression in GD15 mouse testis
  • to study its effects on amyloid β production
  • to study its effects on neurogenic activity of neural stem cells in the adult hippocampus

Biochem/physiol Actions

NBI 27914 is a CRF1 corticotropin-releasing factor receptor antagonist.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
059K4624V
0000022191
0000014267
059K4624
127K46032

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The stress response neuropeptide CRF increases amyloid-beta production by regulating gamma-secretase activity
Park H J, et al.
The Embo Journal, 34(12), 1674-1686 (2015)
A transcriptome-wide screen for mRNAs enriched in fetal Leydig cells: CRHR1 agonism stimulates rat and mouse fetal testis steroidogenesis
McDowell E N, et al.
PLoS ONE, 7(10), e47359-e47359 (2012)
CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus
Koutmani Y, et al.
Testing, 29(4), 932-945 (2019)
Takatoshi Kasai et al.
Cell reports, 30(1), 18-24 (2020-01-09)
The pituitary is a major hormone center that secretes systemic hormones responding to hypothalamus-derived-releasing hormones. Previously, we reported the independent pituitary induction and hypothalamic differentiation of human embryonic stem cells (ESCs). Here, a functional hypothalamic-pituitary unit is generated using human

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