N3911
NBI 27914
≥98% (HPLC)
Synonym(s):
5-Chloro-4-(N-(cyclopropyl)methyl-N-propylamino)-2-methyl-6-(2,4,6-trichlorophenyl)aminopyridine
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About This Item
Empirical Formula (Hill Notation):
C18H20Cl4N4
CAS Number:
Molecular Weight:
434.19
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality Segment
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: >20 mg/mL at 60 °C, H2O: insoluble
storage temp.
2-8°C
SMILES string
CCCN(CC1CC1)c2nc(C)nc(Nc3c(Cl)cc(Cl)cc3Cl)c2Cl
InChI
1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
InChI key
KNADXBVKFAUMCR-UHFFFAOYSA-N
Gene Information
human ... CRHR1(1394)
Application
NBI 27914 has been used as acorticotropin-releasing hormone receptor (CRHR1) antagonist:
- to study its effects on steroidogenic gene expression in GD15 mouse testis
- to study its effects on amyloid β production
- to study its effects on neurogenic activity of neural stem cells in the adult hippocampus
Biochem/physiol Actions
NBI 27914 is a CRF1 corticotropin-releasing factor receptor antagonist.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| N3911-10MG | 04061832898995 |
| N3911-50MG | 04061832899008 |