N4766
N-Nitroso-N-methylurea
Bulk package
Synonym(s):
MNU, N-Methyl-N-nitrosourea
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About This Item
Empirical Formula (Hill Notation):
C2H5N3O2
CAS Number:
Molecular Weight:
103.08
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
form
solid
contains
aqueous acetic acid as stabilizer
storage temp.
2-8°C
SMILES string
CN(N=O)C(N)=O
InChI
1S/C2H5N3O2/c1-5(4-7)2(3)6/h1H3,(H2,3,6)
InChI key
ZRKWMRDKSOPRRS-UHFFFAOYSA-N
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Biochem/physiol Actions
DNA alkylating agent that is carcinogenic in many animal species. Although it can induce benign and malignant tumors in most organs, MNU is most often used to model mammary tumor initiation and progression.
Packaging
Weight on dry basis.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral - Carc. 1B - Flam. Sol. 2 - Repr. 1B
Storage Class Code
4.1B - Flammable solid hazardous materials
WGK
WGK 1
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
监管及禁止进口产品
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Weiqin Jiang et al.
Cancer research, 72(15), 3795-3806 (2012-06-02)
An increased ratio of dietary n-3 relative to n-6 fatty acids has been shown to inhibit the development of mammary cancer in animal models. However, the molecular mechanisms by which n-3 fatty acids affect tumor growth remain unknown. Here, we
Yong Soon Chun et al.
Carcinogenesis, 33(11), 2242-2249 (2012-07-27)
Multiple lines of evidence support a role for curcumin in cancer chemoprevention. Nonetheless, despite its reported efficacy and safety profile, clinical translation of curcumin has been hampered by low oral bioavailability, requiring infeasible 'mega' doses for achieving detectable tissue levels.
Yuan-Yuan Chen et al.
Experimental eye research, 121, 102-113 (2014-02-11)
Mouse retinal degeneration models have been investigated for many years in the hope of understanding the mechanism of photoreceptor cell death. N -methyl- N -nitrosourea (MNU) has been previously shown to induce outer retinal degeneration in mice. After MNU was
Marzena Kurowska et al.
Mutation research, 738-739, 52-70 (2012-10-23)
We present studies aimed at determining the types and frequencies of mutations induced in the barley genome after treatment with chemical (N-methyl-N-nitrosourea, MNU) and physical (gamma rays) mutagens. We created M(2) populations of a doubled haploid line and used them
Bianca F Gonçalves et al.
The Prostate, 73(11), 1202-1213 (2013-04-27)
Characterization of novel rodent models for prostate cancer studies requires evaluation of either spontaneous and carcinogen-induced tumors as well as tumor incidence in different prostatic lobes. We propose a new short-term rodent model of chemically induced prostate carcinogenesis in which
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