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N4788

Anti-NOTCH1 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Notch homolog 1 (Drosophila), Anti-TAN1

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
8
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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

immunohistochemistry: 1:100-1:200, western blot: 1:500-1:1,000

UniProt accession no.

P46531

application(s)

research pathology

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NOTCH1(4851)
mouse ... Notch1(18128)
rat ... Notch1(25496)

General description

NOTCH homolog-1 (NOTCH-1) is a transmembrane receptor.

Immunogen

synthetic peptide corresponding to residues 2170-2187 of human NOTCH1.

Biochem/physiol Actions

NOTCH homolog-1 (NOTCH-1) is an integral part of the NOTCH signaling pathway, which regulates various cellular functions. NOTCH-1 enhances the invasion of cancer cells and mutations in the gene encoding it have been associated with chronic lymphocytic leukemia (CLL).

Physical form

solution in phosphate buffered saline, containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

低风险生物材料
常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number
118K0430
068K0498

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Related Content

Data Sheet - N4788

Instructions

John J Arcaroli et al.
International journal of cancer, 138(1), 195-205 (2015-07-15)
Dysregulation of the Notch1 receptor has been shown to facilitate the development and progression of colorectal cancer (CRC) and has been identified as an independent predictor of disease progression and worse survival. Although mutations in the NOTCH1 receptor have not
Zhen-Shu Xu et al.
Oncology reports, 33(4), 1609-1614 (2015-01-31)
NOTCH1 mutations occur in approximately 10% of patients with chronic lymphocytic leukemia (CLL). However, the relationship between the genetic aberrations and tumor cell drug resistance or disease progression remains unclear. Frameshift deletions were detected by gene sequencing in the NOTCH1
Zhiming Zhuang et al.
Oncology letters, 14(3), 3437-3444 (2017-09-21)
Notch 1 is a key component of the Notch pathway, which performs a crucial role in clear cell renal cell carcinoma (CCRCC) development. The present study aimed to investigate whether Notch 1 could serve as a potential target for CCRCC
View All Related Papers

Global Trade Item Number

SKUGTIN
N4788-100UG04061834116745