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Merck
CN

N4912

NMA-Gly-Cys-Gly-Val-Leu-Leu-Lys(dnp)-Arg-Arg-NH2 trifluoroacetate salt

≥95% (HPLC), solid

Synonym(s):

NMA-GCGVLLK(dnp)RR-NH2

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About This Item

Empirical Formula (Hill Notation):
C56H90N20O14S · xC2HF3O2
Molecular Weight:
1299.50 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD08277027

Key Documents

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SMILES string

FC(F)(F)C(=O)O.SC[C@H](NC(=O)CNC(=O)[C@@H](NC)CC(=O)O)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNc1c(cc(cc1)[N+](=O)[O-])[N+](=O)[O-])C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N

InChI key

RHLODBFQRYLALJ-ZWIFCGJVSA-N

assay

≥95% (HPLC)

form

solid

storage condition

desiccated, protect from light, under inert gas

color

yellow

solubility

H2O: ≥0.5 mg/mL

shipped in

wet ice

storage temp.

−20°C

Biochem/physiol Actions

Notch 1 Peptide, fluorogenic

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
095K4704

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Yoshihito Taniguchi et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(6), 4014-4019 (2002-03-14)
Notch receptors undergo three distinct proteolytic cleavages during maturation and activation. The third cleavage occurs within the plasma membrane and results in the release and translocation of the intracellular domain into the nucleus to execute Notch signaling. This so-called gamma-secretase

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