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N5017

Neuropeptide Y human

Name: Neuropeptide Y human
Brand: SIGMA

≥95% (HPLC), powder, synthetic

Synonym(s):

NPY, hNPY

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About This Item

Empirical Formula (Hill Notation):

C₁₈₉H₂₈₅N₅₅O₅₇S

CAS Number:

90880-35-6

Molecular Weight:

4271.68

UNSPSC Code:

12352200

NACRES:

NA.32

MDL number:

MFCD00212432

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Properties

biological source

synthetic

Quality Segment

200

assay

≥95% (HPLC)

form

powder

color

white

solubility

H₂O: 1 mg/mL

UniProt accession no.

P01303

storage temp.

−20°C

SMILES string

S(CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]6N(CCC6)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]7N(CCC7)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]8N(CCC8)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]9N(CCC9)C(=O)[C@@H](N)Cc%10ccc(cc%10)O)CO)C

InChI

1S/C189H285N55O57S/c1-15-93(7)148(179(295)234-128(81-140(193)254)168(284)226-123(74-92(5)6)171(287)239-149(94(8)16-2)180(296)240-150(99(13)247)181(297)222-115(31-22-67-208-189(202)203)156(272)220-117(56-59-139(192)253)161(277)218-113(29-20-65-206-187(198)199)157(273)224-121(151(195)267)76-101-38-48-107(249)49-39-101)238-172(288)126(79-104-44-54-110(252)55-45-104)229-167(283)127(80-105-86-204-90-210-105)230-159(275)114(30-21-66-207-188(200)201)219-164(280)122(73-91(3)4)225-154(270)96(10)212-173(289)133(88-245)236-166(282)125(78-103-42-52-109(251)53-43-103)228-165(281)124(77-102-40-50-108(250)51-41-102)227-158(274)112(28-19-64-205-186(196)197)216-152(268)95(9)211-155(271)119(62-72-302-14)221-169(285)130(84-146(263)264)232-162(278)118(58-61-144(259)260)217-153(269)97(11)213-176(292)136-33-24-68-241(136)182(298)98(12)214-163(279)129(83-145(261)262)231-160(276)116(57-60-143(257)258)215-142(256)87-209-175(291)135-32-23-70-243(135)185(301)132(82-141(194)255)235-170(286)131(85-147(265)266)233-177(293)138-35-26-71-244(138)184(300)120(27-17-18-63-190)223-174(290)134(89-246)237-178(294)137-34-25-69-242(137)183(299)111(191)75-100-36-46-106(248)47-37-100/h36-55,86,90-99,111-138,148-150,245-252H,15-35,56-85,87-89,190-191H2,1-14H3,(H2,192,253)(H2,193,254)(H2,194,255)(H2,195,267)(H,204,210)(H,209,291)(H,211,271)(H,212,289)(H,213,292)(H,214,279)(H,215,256)(H,216,268)(H,217,269)(H,218,277)(H,219,280)(H,220,272)(H,221,285)(H,222,297)(H,223,290)(H,224,273)(H,225,270)(H,226,284)(H,227,274)(H,228,281)(H,229,283)(H,230,275)(H,231,276)(H,232,278)(H,233,293)(H,234,295)(H,235,286)(H,236,282)(H,237,294)(H,238,288)(H,239,287)(H,240,296)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H4,196,197,205)(H4,198,199,206)(H4,200,201,207)(H4,202,203,208)/t93-,94-,95-,96-,97-,98-,99+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,148-,149-,150-/m0/s1

InChI key

XKWCTHKJQNUFOQ-HRPSIEBRSA-N

Gene Information

human ... NPY(4852)

Description

General description

Neuropeptide Y is a regulatory molecule encoded by a gene mapped to human chromosome 7p15. Neuropeptide Y is a 36 amino acid protein with C-terminal α-amide structure. It is ubiquitously distributed in heart and brain, but at high levels in paraventricular hypothalamic nucleus, hypothalamic arcuate nucleus, suprachiasmatic nucleus, median eminence, dorsomedial, hypothalamic nucleus, paraventricular thalamic nuclei. NPY is a member of antimicrobial peptide family, which also include dermaseptins, cecropins or magainins.

Application

Neuropeptide Y (NPY) human has been used:

to study the effect of antiepileptic effects on pentylenetetrazole (PTZ) rats.
as a standard in high-performance liquid chromatography (HPLC) standard and control to verify specificity of the antibodies.
to study the effect of NPY on motor and electroencephalographic (EEG) seizures induced by kainic acid.

Biochem/physiol Actions

Neuropeptide Y (NPY) plays a vital role in various processes including feeding behaviour, anxiety, epilepsy, circadian, as well as rhythm memory processing, sleep, pain and drug addiction. In addition, it is also implicated in regulation of appetite, body weight and obesity. It controls central endocrine secretion and has potent vasoactive effects on the cardiovascular system. NPY is involved in the pathogenesis of atherosclerosis and coronary artery disease. NPY exhibits antimicrobial activity against Cryptococcus neoformans, Candida albicans and Arthroderma simii.

Vasoconstrictor; brain peptide that inhibits Ca²⁺-activated K⁺ channels in vascular smooth muscle. Implicated in the control of blood pressure, sexual behavior and food intake. Inhibits cholecystokinin- and secretin-stimulated pancreatic secretion.

Vasoconstrictor; inhibits Ca²⁺-activated K⁺ channels in vascular smooth muscle; inhibits cholecystokinin- and secretin-stimulated pancreatic secretion.

Other Notes

Lyophilized from 0.1% TFA in H2O

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c