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N5266

Neurotensin Fragment 8-13 acetate salt

Name: Neurotensin Fragment 8-13 acetate salt
Brand: SIGMA

≥97% (HPLC), suitable for ligand binding assays

Synonym(s):

L-arginyl-L-arginyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine

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About This Item

Empirical Formula (Hill Notation):

C₃₈H₆₄N₁₂O₈

CAS Number:

60482-95-3

Molecular Weight:

816.99

UNSPSC Code:

12352209

PubChem Substance ID:

24897727

NACRES:

NA.26

MDL number:

MFCD00076686

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Product Name

Neurotensin Fragment 8-13 acetate salt, ≥97% (HPLC)

Quality Level

200

assay

≥97% (HPLC)

form

powder

technique(s)

ligand binding assay: suitable

color

white

application(s)

cell analysis

storage temp.

−20°C

SMILES string

CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C2CCCN2C(=O)C(CCCNC(N)=N)NC(=O)C(N)CCCNC(N)=N)C(=O)NC(CC(C)C)C(O)=O

InChI

1S/C38H64N12O8/c1-5-22(4)30(34(55)48-28(36(57)58)19-21(2)3)49-32(53)27(20-23-12-14-24(51)15-13-23)47-33(54)29-11-8-18-50(29)35(56)26(10-7-17-45-38(42)43)46-31(52)25(39)9-6-16-44-37(40)41/h12-15,21-22,25-30,51H,5-11,16-20,39H2,1-4H3,(H,46,52)(H,47,54)(H,48,55)(H,49,53)(H,57,58)(H4,40,41,44)(H4,42,43,45)

InChI key

DQDBCHHEIKQPJD-UHFFFAOYSA-N

Related Categories

Biochemicals

Cell Culture Supplements & Reagents

Amino Acids – Building Blocks of Life Science

Biochem/physiol Actions

Neurotensin Fragment 8-13 acetate salt is the smallest active fragment of neurotensin.

Other Notes

Smallest active fragment of neurotensin

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number

0000497547

0000487775

0000351531

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Determination of peptide hormones of brain and intestine by CE with ESI-MS detection.

Shifei Xia et al.

Electrophoresis, 28(18), 3268-3276 (2007-09-15)

A new method for the determination of the peptide hormones of brain and intestine based on CE coupling with a DAD and ESI-MS was established. Several electrophoretic and ESI-MS parameters were investigated in detail, such as electrolyte nature and concentration

Neurotensin(8-13) analogue: radiolabeling and biological evaluation using different chelators.

Rodrigo Teodoro et al.

Nuclear medicine and biology, 38(1), 113-120 (2011-01-12)

Several strategies on the development of radiopharmaceuticals have been employed. Bifunctional chelators seem to be a promising approach since high radiochemical yields as well as good in vitro and in vivo stability have been achieved. To date, neurotensin analogs have

Novel 99mTc-labeled neurotensin analogues with optimized biodistribution properties.

Veronique Maes et al.

Journal of medicinal chemistry, 49(5), 1833-1836 (2006-03-03)

Two new 99mTc-labeled neurotensin(8-13) analogues containing the retro-N(alpha)-carboxymethyl-histidine ((N(alpha)His)Ac) chelator were synthesized as potential radiopharmaceuticals for visualization of pancreatic carcinoma. To improve the pharmacokinetic properties, (N(alpha)His)Ac-Arg-NMeArg-Pro-Tyr-Tle-Leu (NT-XII), which is metabolically stabilized at two positions, was further modified. Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic

In vitro analysis of stable, receptor-selective neurotensin[8-13] analogues.

Kyle P Kokko et al.

Journal of medicinal chemistry, 46(19), 4141-4148 (2003-09-05)

A set of neurotensin[8-13] (NT[8-13]) analogues featuring substitution of non-natural cationic amino acids in the Arg(8) position have been synthesized and tested for binding potencies against the three cloned human NT receptors (hNTR-1, hNTR-2, hNTR-3), functional agonism of the hNTR1

Probing the environment of neurotensin whilst bound to the neurotensin receptor by solid state NMR.

P T F Williamson et al.

FEBS letters, 518(1-3), 111-115 (2002-05-09)

A functionally active analogue of neurotensin, neurotensin(8-13), has been observed whilst bound to the agonist-binding site of the rat neurotensin receptor by nuclear magnetic resonance (NMR). Through the application of slow magic angle sample spinning and high-power proton decoupling, sufficient

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Global Trade Item Number

SKU	GTIN
N5266-5MG	04061832821955
N5266-1MG	04061826285695

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