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Merck
CN

N5504

Naphazoline hydrochloride

Synonym(s):

2-(1-Naphthylmethyl)imidazoline hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C14H14N2 · HCl
CAS Number:
550-99-2
Molecular Weight:
246.74
EC Number:
208-989-2
MDL number:
MFCD00012554
UNSPSC Code:
12352200
PubChem Substance ID:
24278592
NACRES:
NA.77

Key Documents

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form

powder

Quality Level

100

originator

Allergan

SMILES string

Cl.C1CN=C(Cc2cccc3ccccc23)N1

InChI

1S/C14H14N2.ClH/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;/h1-7H,8-10H2,(H,15,16);1H

InChI key

DJDFFEBSKJCGHC-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

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Related Categories

Biochem/physiol Actions

α-adrenoceptor agonist; imidazoline receptor agonist; vasoconstrictor.
Naphazoline hydrochloride is a sympathomimetic agent. It is also considered as a conjunctival decongestant.

Features and Benefits

This compound was developed by Allergan. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM0849
BCCM0848
BCCH9982
BCCG7846
BCCD1190

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Robert Fuchs et al.
Experimental cell research, 317(20), 2969-2980 (2011-08-20)
Even though the erythroleukemia cell lines K562 and HEL do not express α1-adrenoceptors, some α1-adrenergic drugs influence both survival and differentiation of these cell lines. Since Ca2+ is closely related to cellular homeostasis, we examined the capacity of α1-adrenergic drugs
Shizhong Zhu et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 98, 142-147 (2012-09-22)
The fluorescence and ultraviolet spectroscopy were explored to study the interaction between Naphazoline hydrochloride (Naphcon) and bovine serum albumin (BSA) at three different temperatures (292, 301, and 310 K) under imitated physiological conditions. The quenching mechanism of BSA by Naphacon
Yuriko Nagane et al.
Muscle & nerve, 44(1), 41-44 (2011-04-15)
When treating ocular myasthenia gravis (MG), the risk/benefit profile of corticosteroids is unclear, and acetylcholinesterase inhibitors are not very effective. We examined the efficacy of topical naphazoline in the treatment of myasthenic blepharoptosis. Sixty MG patients with blepharoptosis (32 with
Nan-Nan Wang et al.
Luminescence : the journal of biological and chemical luminescence, 24(3), 178-182 (2009-03-03)
A sensitive and simple flow-injection chemiluminescence (FI-CL) method, which was based on the CL intensity generated from the redoxreaction of potassium permanganate (KMnO4)-formaldehyde in vitriol (H2SO4) medium, has been developed, validated and applied for the determination of naphazoline hydrochloride and
Marie Granier et al.
Canadian journal of anaesthesia = Journal canadien d'anesthesie, 56(2), 102-108 (2009-02-28)
Septorhinoplasty is a traumatic procedure that is associated with epistaxis and postoperative pain. The primary objective of this randomized double-blind controlled trial was to determine whether intranasal 5% lidocaine plus naphazoline decreases postoperative pain and lessens the use of rescue
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