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Merck
CN

N5538

Monoclonal Anti-3-Nitrotyrosine antibody produced in mouse

clone 18G4, purified immunoglobulin, buffered aqueous glycerol solution

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

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Product Name

Monoclonal Anti-3-Nitrotyrosine antibody produced in mouse, clone 18G4, purified immunoglobulin, buffered aqueous glycerol solution

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

18G4, monoclonal

form

buffered aqueous glycerol solution

mol wt

antigen ~55 kDa

species reactivity

wide range

technique(s)

western blot: 1:1,000 using mouse and rat brain

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

nitration (Tyr)

Gene Information

human ... NOS1(4842)

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Application

Monoclonal Anti-3-Nitrotyrosine antibody produced in mouse has been used in western blot analysis and immunohistochemistry.

Biochem/physiol Actions

3-Nitrotyrosine (3-NT) in tissue extracts is a marker for the determination of protein damage induced by peroxynitrite. 3-NT is used as a biomarker to determine the protein nitration, associated with various disorders. It is implicated in diseases characterized by endothelial dysfunction as in stroke, myocardial infarction, atherosclerosis and diabetes.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

3-nitrotyrosine (3-NT) is synthesized by the incorporation of nitro triatomic group (-NO2) at the third position of the phenolic ring in the tyrosine residue, in response to the production of peroxynitrite in the oxidative and nitrosative stress.
Monoclonal Anti-3-Nitrotyrosine recognizes 3-nitrotyrosine in most species. Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxide signaling.

Immunogen

3-Nitrotyrosine-KLH.

Physical form

Solution in 20 mM sodium phosphate, 150 mM sodium chloride, 50% glycerol, and 3 mM sodium azide.

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBP5162V
SLBM3397V
SLBJ6916V
SLBJ6916
SLBC5716

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Related Content

Data Sheet - N5538

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