N5538
Monoclonal Anti-3-Nitrotyrosine antibody produced in mouse
clone 18G4, purified immunoglobulin, buffered aqueous glycerol solution
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
18G4, monoclonal
Application:
WB
Citations:
17
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
18G4, monoclonal
form
buffered aqueous glycerol solution
mol wt
antigen ~55 kDa
species reactivity
wide range
technique(s)
western blot: 1:1,000 using mouse and rat brain
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
nitration (Tyr)
Gene Information
human ... NOS1(4842)
General description
3-nitrotyrosine (3-NT) is synthesized by the incorporation of nitro triatomic group (-NO2) at the third position of the phenolic ring in the tyrosine residue, in response to the production of peroxynitrite in the oxidative and nitrosative stress.
Monoclonal Anti-3-Nitrotyrosine recognizes 3-nitrotyrosine in most species. Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxide signaling.
Immunogen
3-Nitrotyrosine-KLH.
Application
Monoclonal Anti-3-Nitrotyrosine antibody produced in mouse has been used in western blot analysis and immunohistochemistry.
Biochem/physiol Actions
3-Nitrotyrosine (3-NT) in tissue extracts is a marker for the determination of protein damage induced by peroxynitrite. 3-NT is used as a biomarker to determine the protein nitration, associated with various disorders. It is implicated in diseases characterized by endothelial dysfunction as in stroke, myocardial infarction, atherosclerosis and diabetes.
Physical form
Solution in 20 mM sodium phosphate, 150 mM sodium chloride, 50% glycerol, and 3 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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