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N6127

19-Norethindrone acetate

Name: 19-Norethindrone acetate
Brand: SIGMA

Synonym(s):

17α-Ethynyl-17β-hydroxy-19-nor-4-androsten-3-one 17-acetate, 17α-Ethynyl-19-nortestosterone 17β-acetate, 17-Hydroxy-19-nor-17α-4-pregnen-20-yn-3-one acetate, 19-Norethisterone 17-acetate

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₈O₃

CAS Number:

51-98-9

Molecular Weight:

340.46

UNSPSC Code:

41116107

PubChem Substance ID:

24897767

EC Number:

200-132-0

MDL number:

MFCD00271615

Assay:

≥98.00% (HPLC)

Form:

powder

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Properties

assay

≥98.00% (HPLC)

form

powder

solubility

chloroform: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

CC(=O)O[C@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@]12C)C#C

InChI

1S/C22H28O3/c1-4-22(25-14(2)23)12-10-20-19-7-5-15-13-16(24)6-8-17(15)18(19)9-11-21(20,22)3/h1,13,17-20H,5-12H2,2-3H3/t17-,18+,19+,20-,21-,22-/m0/s1

InChI key

IMONTRJLAWHYGT-ZCPXKWAGSA-N

Gene Information

human ... PGR(5241)

Description

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pictograms

GHS08,GHS09

signalword

Danger

hcodes

H351,H360FD,H362,H410

pcodes

P202 - P260 - P263 - P264 - P273 - P308 + P313

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Digitized assessment of mammographic breast density--effects of continuous combined hormone therapy, tibolone and black cohosh compared to placebo.

E Lundström et al.

Maturitas, 70(4), 361-364 (2011-10-01)

To determine the effects of continuous combined hormone therapy, tibolone, black cohosh, and placebo on digitized mammographic breast density in postmenopausal women. A prospective, double-blind, placebo-controlled study of 154 postmenopausal women randomized to estradiol 2 mg/norethisterone acetate 1 mg (E2/NETA)

Differential regulation of endogenous pro-inflammatory cytokine genes by medroxyprogesterone acetate and norethisterone acetate in cell lines of the female genital tract.

Donita Africander et al.

Contraception, 84(4), 423-435 (2011-09-17)

Medroxyprogesterone acetate (MPA) and norethisterone (NET) and its derivatives are widely used in female reproductive therapy, but little is known about their mechanisms of action via steroid receptors in the female genital tract. MPA used as a contraceptive has been

Effects of combined hormone replacement therapy or its effective agents on the IGF-1 pathway in skeletal muscle.

Eija Pöllänen et al.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 20(5), 372-379 (2010-08-21)

To investigate the effects of combined hormone replacement therapy (HRT) and its effective agents on the IGF-1 signaling pathway. To examine the effects of HRT on skeletal muscle in vivo, we utilized pre- and post-intervention samples from a randomized double

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