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N6756

Nicotinamide hypoxanthine dinucleotide, reduced form, sodium salt

Name: Nicotinamide hypoxanthine dinucleotide, reduced form, sodium salt
Brand: SIGMA

Grade I, ≥95%

Synonym(s):

Deamino DPNH, Deamino NADH, Deaminodiphosphopyridine nucleotide, reduced form

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₈N₆O₁₅P₂ · xNa⁺

Molecular Weight:

666.43 (free acid basis)

NACRES:

NA.51

PubChem Substance ID:

24897791

UNSPSC Code:

41106305

MDL number:

MFCD00057030

Form:

powder

Assay:

≥95%

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type

Grade I

Quality Level

200

assay

≥95%

form

powder

storage temp.

−20°C

SMILES string

NC(=O)C1=CN(C=CC1)C2OC(COP(O)(=O)OP(O)(=O)OCC3OC(C(O)C3O)n4cnc5C(=O)N=CNc45)C(O)C2O

InChI

1S/C21H28N6O15P2/c22-17(32)9-2-1-3-26(4-9)20-15(30)13(28)10(40-20)5-38-43(34,35)42-44(36,37)39-6-11-14(29)16(31)21(41-11)27-8-25-12-18(27)23-7-24-19(12)33/h1,3-4,7-8,10-11,13-16,20-21,28-31H,2,5-6H2,(H2,22,32)(H,34,35)(H,36,37)(H,23,24,33)

InChI key

WXWNHSQIXJHVJY-UHFFFAOYSA-N

Application

Nicotinamide hypoxanthine dinucleotide, reduced (deamino-NADH) may be used study the specificity and kinetics of NADH: ubiquinone oxidoreductase(s).

Preparation Note

Enzymatically reduced.

Other Notes

Analog of β-NADH

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000513816

0000481037

SLCD6369

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Mitochondrial DNA background modulates the assembly kinetics of OXPHOS complexes in a cellular model of mitochondrial disease.

Rosa Pello et al.

Human molecular genetics, 17(24), 4001-4011 (2008-09-23)

Leber's hereditary optic neuropathy (LHON), the most frequent mitochondrial disorder, is mostly due to three mitochondrial DNA (mtDNA) mutations in respiratory chain complex I subunit genes: 3460/ND1, 11778/ND4 and 14484/ND6. Despite considerable clinical evidences, a genetic modifying role of the

Leber hereditary optic neuropathy mutations in the ND6 subunit of mitochondrial complex I affect ubiquinone reduction kinetics in a bacterial model of the enzyme.

Jukka Pätsi et al.

The Biochemical journal, 409(1), 129-137 (2007-09-27)

LHON (Leber hereditary optic neuropathy) is a maternally inherited disease that leads to sudden loss of central vision at a young age. There are three common primary LHON mutations, occurring at positions 3460, 11778 and 14484 in the human mtDNA

HQNO-sensitive NADH:quinone oxidoreductase of Bacillus cereus KCTC 3674.

Jiwon Kang et al.

Journal of biochemistry and molecular biology, 40(1), 53-57 (2007-01-25)

The enzymatic properties of NADH:quinone oxidoreductase were examined in Triton X-100 extracts of Bacillus cereus membranes by using the artificial electron acceptors ubiquinone-1 and menadione. Membranes were prepared from B. cereus KCTC 3674 grown aerobically on a complex medium and

Modeling of human pathogenic mutations in Escherichia coli complex I reveals a sensitive region in the fourth inside loop of NuoH.

Pilvi Maliniemi et al.

Mitochondrion, 9(6), 394-401 (2009-07-21)

Seven of the 45 subunits of mitochondrial NADH:ubiquinone oxidoreductase (complex I) are mitochondrially encoded and have been shown to harbor pathogenic mutations. We modeled the human disease-associated mutations A4136G/ND1-Y277C, T4160C/ND1-L285P and C4171A/ND1-L289M in a highly conserved region of the fourth

Mitochondrial dehydrogenases in the aerobic respiratory chain of the rodent malaria parasite Plasmodium yoelii yoelii.

Kenji Kawahara et al.

Journal of biochemistry, 145(2), 229-237 (2008-12-09)

In the intraerythrocytic stages of malaria parasites, mitochondria lack obvious cristae and are assumed to derive energy through glycolysis. For understanding of parasite energy metabolism in mammalian hosts, we isolated rodent malaria mitochondria from Plasmodium yoelii yoelii grown in mice.

Global Trade Item Number

SKU	GTIN
N6756-25MG	04061833264355
N6756-250MG	04061833264348

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