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N7261

Nortriptyline hydrochloride

Name: Nortriptyline hydrochloride
Brand: SIGMA

≥98% (HPLC), norepinephrine and serotonin inhibitor, powder

Synonym(s):

3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine hydrochloride, Desmethylamitriptyline hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₁N · HCl

CAS Number:

894-71-3

Molecular Weight:

299.84

NACRES:

NA.77

PubChem Substance ID:

24278107

UNSPSC Code:

41116107

EC Number:

212-973-0

MDL number:

MFCD00058024

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

200

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Product Name

Nortriptyline hydrochloride, ≥98% (HPLC), powder

Quality Level

200

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

ethanol: 100 mg/mL, H₂O: soluble

originator

Eli Lilly

SMILES string

Cl.CNCC\C=C1\c2ccccc2CCc3ccccc13

InChI

1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H

InChI key

SHAYBENGXDALFF-UHFFFAOYSA-N

Gene Information

human ... HTR2A(3356), HTR2B(3357), HTR2C(3358), SLC6A2(6530), SLC6A4(6532)

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Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Biochem/physiol Actions

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (K_i = 3.4 nM) than the serotonin transporter (K_i = 161 nM). 5-HT₂ serotonin receptor antagonist.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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X-ray structure of dopamine transporter elucidates antidepressant mechanism.

Aravind Penmatsa et al.

Nature, 503(7474), 85-90 (2013-09-17)

Antidepressants targeting Na(+)/Cl(-)-coupled neurotransmitter uptake define a key therapeutic strategy to treat clinical depression and neuropathic pain. However, identifying the molecular interactions that underlie the pharmacological activity of these transport inhibitors, and thus the mechanism by which the inhibitors lead

Non-random dropout and the relative efficacy of escitalopram and nortriptyline in treating major depressive disorder.

Robert A Power et al.

Journal of psychiatric research, 46(10), 1333-1338 (2012-07-10)

Most comparisons of the efficacy of antidepressants have relied on the assumption that missing data are randomly distributed. Dropout rates differ between drugs, suggesting this assumption may not hold true. This paper examines the effect of non-random dropout on a

Alternative calibration strategies for the clinical laboratory: application to nortriptyline therapeutic drug monitoring.

Matthew T Olson et al.

Clinical chemistry, 59(6), 920-927 (2013-02-22)

The addition of a calibration curve with every run is both time-consuming and expensive for clinical mass spectrometry assays. We present alternative calibration strategies that eliminate the need for a calibration curve except as required by laboratory regulations. We measured

Behavioural interventions as adjuncts to pharmacotherapy for smoking cessation.

Lindsay F Stead et al.

The Cochrane database of systematic reviews, 12, CD009670-CD009670 (2012-12-14)

Effective pharmacotherapies are available to help people who are trying to stop smoking, but quitting can still be difficult and providing higher levels of behavioural support may increase success rates further. To evaluate the effect of increasing the intensity of

SSRIs: a premature burial.

K Jensen

Clinical pharmacology and therapeutics, 93(3), 234-235 (2012-12-20)

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Global Trade Item Number

SKU	GTIN
N7261-10G	04061834117940

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