N7764
Nicotinic acid mononucleotide
Synonym(s):
Nicotinate mononucleotide
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About This Item
Empirical Formula (Hill Notation):
C11H14NO9P
CAS Number:
Molecular Weight:
335.20
NACRES:
NA.79
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Assay:
≥98.0% (HPLC)
Biological source:
animal
Form:
powder
Storage temp.:
−20°C
biological source
animal
Quality Segment
assay
≥98.0% (HPLC)
form
powder
technique(s)
HPLC: suitable
color
white
storage temp.
−20°C
SMILES string
OC1C(O)C(OC1COP(O)(O)=O)[N]2=CC(=CC=C2)C(O)=O
InChI
1S/C11H15NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H,15,16)(H2,17,18,19)
InChI key
IUJWGLOJJKFASX-UHFFFAOYSA-N
General description
Nicotinic acid mononucleotide (NaMN) is formed from nicotinic acid 5-phosphoribosyl-1-pyrophosphate (PRPP) in the Preiss-Handler pathway in the presence of enzyme phosphoribosyltransferase (NaPRT).
Application
Nicotinic acid mononucleotide has been used as a substrate for NMN/NaMN adenylyltransferase (NMNAT) during nicotinamide adenine dinucleotide (NAD) biosynthesis.
Biochem/physiol Actions
Nicotinic acid mononucleotide (NaMN) may be used to study the relationship between the phosphate-responsive signaling (PHO) pathway and nicotine adenine dinucleotide (NAD(+)) metabolism in yeast. Nicotinate mononucleotide is a substrate for NMN/NaMN adenylyltransferase (NMNAT) and nicotinate mononucleotide adenylyltransferase. NaMN amidation results in the synthesis of nicotinamide mononucleotide(NMN), which is further converted to NAD cofactor.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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