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Merck
CN

N8000

1-Naphthyl butyrate

esterase substrate, ≥99% (GC), liquid

Synonym(s):

Butanoic acid 1-naphthyl ester, Butyric acid 1-naphthyl ester

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About This Item

Linear Formula:
CH3CH2CH2CO2C10H7
CAS Number:
3121-70-8
Molecular Weight:
214.26
NACRES:
NA.32
PubChem Substance ID:
24897845
UNSPSC Code:
12352204
EC Number:
221-500-7
MDL number:
MFCD00003923
Beilstein/REAXYS Number:
2558646

Key Documents

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Product Name

1-Naphthyl butyrate,

InChI

1S/C14H14O2/c1-2-6-14(15)16-13-10-5-8-11-7-3-4-9-12(11)13/h3-5,7-10H,2,6H2,1H3

InChI key

XIVJNRXPRQKFRZ-UHFFFAOYSA-N

SMILES string

CCCC(=O)Oc1cccc2ccccc12

Quality Level

200

assay

≥99% (GC)

form

liquid

bp

125-130 °C/1 mmHg (lit.)

solubility

ethanol: 100 mg/mL, clear, colorless to faintly yellow

density

1.091 g/mL at 20 °C (lit.)

storage temp.

−20°C

General description

Esterase substrate.

Application

1-Naphthyl butyrate has been used as a substrate for esterase activity in sheep body louse Bovicola ovis and in chromogenic staining of flounder fish samples.

Biochem/physiol Actions

1-Naphthyl butyrate also called α-naphthyl butyrate is a substrate for esterase enzyme. α-naphthyl butyrate aids in assessing α-naphthyl butyrate esterase activity in monocytes and lymphocytes.

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

143.6 °F - closed cup

flash_point_c

62 °C - closed cup

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLCM6290
0000430007
0000430007
0000225467
0000225467

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M S Levine et al.
Journal of occupational medicine. : official publication of the Industrial Medical Association, 28(3), 207-211 (1986-03-01)
A cross-sectional review of routine employee health status examinations has identified an undercounting of circulating monocytes associated with an inhibition of a surface monocyte esterase, alpha-naphthyl butyrate esterase. It is postulated that this inhibition is associated with an organophosphate used
T Honda et al.
Histochemistry, 77(3), 299-302 (1983-01-01)
The proteases of human leukocytes were cytochemically studied by use of new alpha-naphthyl esters, tosyl-L-lysine-alpha-naphthyl ester (TLNE) and acetyl-L-tyrosine-alpha-naphthyl ester (ATNE). The hydrolytic activities were strong only in neutrophils, with both substrates. They were inhibited completely by DFP and chymostatin
Identification of alpha-naphthyl butyrate esterase as a plasma membrane ectoenzyme of monocytes and as a discrete intracellular membrane-bounded organelle in lymphocytes.
Bozdech MJ and Bainton DF
The Journal of Experimental Medicine, 153(1), 182-195 (1981)
Esterases of the flounder (Platichthys flesus, Pleuronectidae, Teleostei): development of an identification protocol using starch gel electrophoresis and characterization of loci
Berrebi P, et al.
Experientia, 46(8), 863-867 (1990)
R B Miller et al.
Journal of biochemical and biophysical methods, 3(6), 345-354 (1980-12-01)
We have developed a spectrophotometric assay method which continuously records esterase activity at 510 nm by monitoring absorbance changes due to the formation of a diazo dye complex. In our method, alpha-naphthyl ester substrates are hydrolyzed by enzymatic action to
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