N8161
NS309
≥98% (HPLC), Ca2+-activated IK/SK potassium channel activator, solid
Synonym(s):
3-Oxime-6,7-dichloro-1H-indole-2,3-dione
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About This Item
Empirical Formula (Hill Notation):
C8H4Cl2N2O2
CAS Number:
Molecular Weight:
231.04
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
NS309, ≥98% (HPLC), solid
Quality Level
assay
≥98% (HPLC)
form
solid
color
yellow
solubility
DMSO: 22 mg/mL
storage temp.
2-8°C
SMILES string
O\N=C1\C(=O)Nc2c(Cl)c(Cl)ccc12
InChI
1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,14H,(H,11,12,13)
InChI key
CVOUSAVHMDXCKG-UHFFFAOYSA-N
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Related Categories
Biochem/physiol Actions
NS309 is a Ca2+-activated IK/SK potassium channel activator.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
air sensitive
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Kanwal Sakhi et al.
The Journal of physiology, 592(4), 587-603 (2013-11-20)
Intrinsic daily or circadian rhythms arise through the outputs of the master circadian clock in the brain's suprachiasmatic nuclei (SCN) as well as circadian oscillators in other brain sites and peripheral tissues. SCN neurones contain an intracellular molecular clock that
Cara C Rada et al.
American journal of physiology. Endocrinology and metabolism, 307(10), E935-E943 (2014-09-25)
Proper placental perfusion is essential for fetal exchange of oxygen, nutrients, and waste with the maternal circulation. Impairment of uteroplacental vascular function can lead to pregnancy complications, including preeclampsia and intrauterine growth restriction (IUGR). Potassium channels have been recognized as
Jensen, B.S., et al.
Abstr. Soc. Neurosci, 2003, 367-367 null
The influence of DOCA-salt hypertension and chronic administration of the FAAH inhibitor URB597 on K
Monika Kloza et al.
Vascular pharmacology, 99, 65-73 (2017-10-19)
The aim of this study was to examine the influence of deoxycorticosterone acetate-salt (DOCA-salt) hypertension and chronic treatment with the fatty acid amide hydrolase inhibitor, URB597, on small and intermediate conductance calcium-activated potassium channels and endothelium-dependent hyperpolarization (K
Jackson T Fontaine et al.
Mechanisms of ageing and development, 192, 111389-111389 (2020-11-01)
Vascular cognitive impairment, the second most common cause of dementia, profoundly affects hippocampal-dependent functions. However, while the growing literature covers complex neuronal interactions, little is known about the sustaining hippocampal microcirculation. Here we examined vasoconstriction to physiological pressures of hippocampal
Global Trade Item Number
| SKU | GTIN |
|---|---|
| N8161-25MG | 04061832575117 |
| N8161-5MG | 04061834118442 |
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