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N8162

NIDA-41020

Name: NIDA-41020
Brand: SIGMA

≥97% (HPLC), solid

Synonym(s):

1-(2,4-Dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₂₄Cl₂N₄O₂

CAS Number:

502486-89-7

Molecular Weight:

459.37

NACRES:

NA.77

PubChem Substance ID:

329818682

UNSPSC Code:

12352200

MDL number:

MFCD08277026

Assay:

≥97% (HPLC)

Form:

solid

Quality level:

100

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Quality Level

100

assay

≥97% (HPLC)

form

solid

color

off-white

solubility

DMSO: ~16 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

COc1ccc(cc1)-c2c(C)c(nn2-c3ccc(Cl)cc3Cl)C(=O)NN4CCCCC4

InChI

1S/C23H24Cl2N4O2/c1-15-21(23(30)27-28-12-4-3-5-13-28)26-29(20-11-8-17(24)14-19(20)25)22(15)16-6-9-18(31-2)10-7-16/h6-11,14H,3-5,12-13H2,1-2H3,(H,27,30)

InChI key

KWDBQJRWPWTGPF-UHFFFAOYSA-N

Biochem/physiol Actions

NIDA-41020 is a CB1 cannabinoid receptor antagonist. NIDA-41020 is structurally similar to Rimonabant, which is currently in clinical development. NIDA-41020 is less lipophilic; developed at NIDA as a potential radioligand for CB₁ receptors, K_i = 4.1 nM [in comparison AM 251, AM 281, SR 141716 (Rimonabant) have K_i of 0.6, 4.5 and 1.8 nM respectively].

NIDA-41020 is a CB₁ cannabinoid receptor antagonist.

pictograms

GHS06

signalword

Danger

hcodes

H300,H315,H319,H335

pcodes

P261 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number

011M4615V

115K4600

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Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity.

Reeti Katoch-Rouse et al.

Journal of medicinal chemistry, 46(4), 642-645 (2003-02-07)

Exploration of the central CB1 cannabinoid receptors using positron emission tomography (PET) will allow for an understanding of the pharmacological and physiological role played by these receptors in the CNS. Current tracers are highly lipophilic compounds that exhibit very high

Keynote review: Medicinal chemistry strategies to CB1 cannabinoid receptor antagonists.

Jos H M Lange et al.

Drug discovery today, 10(10), 693-702 (2005-05-18)

The proven clinical efficacy of the CB(1) cannabinoid receptor antagonist rimonabant in both obesity and smoking cessation and its therapeutic potential in other disorders has given a tremendous impetus to the discovery of novel CB(1) antagonists. The number of disclosed

Global Trade Item Number

SKU	GTIN
N8162-10MG	04061832557595
N8162-50MG	04061832557601

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